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Study of Alpecin
Alpecin Double-Effect Shampoo against dandruff and
20 men aged 18 to 55 who suffer from increased
The test subjects used Alpecin over the course of 6 weeks.
Problem and study objective:
Dandruff as well as the genetic predisposition for hair loss frequently
coincide in men. Due to the impact of the male hormone testosterone, the
sebaceous glands are stimulated, which enhances microbiological growth
and the associated formation of dandruff on the scalp.
Testosterone can also negatively impact hair growth in hereditarily
predisposed hair roots and accelerate hair loss.
The current study was the first to test the anti-dandruff effect of a novel
caffeine shampoo, which contains a caffeine complex as well as an active
ingredient combination against dandruff.
The test was conducted with 20 men aged 18 to 55, who suffered from
increased dandruff. Prior to the test, the test subjects were prepared for the
study with a neutral shampoo. The test shampoos used were the caffeine-
based anti-dandruff shampoo and a comparative market reference product
to which an excellent anti-dandruff effect had been attributed. The shampoos
were used over a time period of 6 weeks. During this time, the microbiological
activity on the scalp as well as the overall amount of dandruff were measured.
The condition of the scalp and the formation of dandruff directly on the scalp
were recorded with special camera technology, and the images were quanti-
tatively categorized upon conclusion of the tests. In a questionnaire, the test
subjects also had the opportunity to provide their subjective assessments of
Graphic 1: Microbiological activity [%]
During the quantitative evaluation of the amount of dandruff, it became
apparent that the overall measurable amount of dandruff decreased very well
in comparison to the market reference product. [Graphic 2]
The antimicrobiological effect against Malassezia furfur (microorganisms) was
also excellent for both products. The number of germs is approximately
The comparison of the scalp images has confirmed the results very well.
Graphic 2: Quantitative dandruff reduction [%]
The subjective assessment of the anti-dandruff effect confirms the quantita-
tive results. From the users’ point of view, the formation of dandruff decreased
significantly. Compared to the market reference product, the test shampoo was
equally effective. However, the comparative study also showed that dandruff
formation on the scalp is subject to strong individual fluctuations and that
neither the test shampoo nor the market reference product eliminated
dandruff completely in all cases during the period of application.
Additional information on hereditary hair loss is provided by the following
Penetration of caffeine from a shampoo formula
Caffeine Complex is Effective in the Treatment of Androgenetic Alopecia
Spermatogonial stem cellpreservation in boys with Klinefeltersyndrome: to bank or not to bank,that's the questionInge Gies, M.D.,a Jean De Schepper, M.D., Ph.D.,a Ellen Goossens, Ph.D.,b Dorien Van Saen, M.Sc.,bGuido Pennings, Ph.D.,c and Herman Tournaye, M.D., Ph.D.b,da Department of Pediatrics, UZ Brussel, Brussels; b Research Group Biology of the Testis, Department of Embryology andGenetics
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