SIGMA-ALDRICH sigma-aldrich.com SAFETY DATA SHEET
according to Regulation (EC) No. 1907/2006
GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA
IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING Product identifiers Product name Relevant identified uses of the substance or mixture and uses advised against
: Laboratory chemicals, Manufacture of substances
Details of the supplier of the safety data sheet
1 Science Park Road #02-14 The Capricorn Singapore Science Park Road II SINGAPORE 117528 SINGAPORE
Emergency telephone number HAZARDS IDENTIFICATION Classification of the substance or mixture Classification according to Regulation (EC) No 1272/2008 [EU-GHS/CLP] Reproductive toxicity (Category 1B) Classification according to EU Directives 67/548/EEC or 1999/45/EC May cause harm to the unborn child. Label elements Labelling according Regulation (EC) No 1272/2008 [CLP] Pictogram
May damage fertility or the unborn child.
IF exposed or concerned: Get medical advice/ attention.
According to European Directive 67/548/EEC as amended. Hazard symbol(s)
Sigma - F4381
Avoid exposure - obtain special instructions before use.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Other hazards - none COMPOSITION/INFORMATION ON INGREDIENTS Substances Synonyms
: 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid
4-Chloro-N-furfuryl-5-sulfamoylanthranilic acid
Furosemide FIRST AID MEASURES Description of first aid measures General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Flush eyes with water as a precaution. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician. Most important symptoms and effects, both acute and delayed To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Indication of any immediate medical attention and special treatment needed no data available FIREFIGHTING MEASURES Extinguishing media Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special hazards arising from the substance or mixture Carbon oxides, nitrogen oxides (NOx), Sulphur oxides, Hydrogen chloride gas Advice for firefighters Wear self contained breathing apparatus for fire fighting if necessary.
Sigma - F4381 Further information no data available ACCIDENTAL RELEASE MEASURES Personal precautions, protective equipment and emergency procedures Use personal protective equipment. Avoid dust formation. Avoid breathing vapors, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. Environmental precautions Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Methods and materials for containment and cleaning up Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal. Reference to other sections For disposal see section 13. HANDLING AND STORAGE Precautions for safe handling Avoid formation of dust and aerosols.Avoid exposure - obtain special instructions before use. Provide appropriate exhaust ventilation at places where dust is formed.Normal measures for preventive fire protection. Conditions for safe storage, including any incompatibilities Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Specific end uses no data available EXPOSURE CONTROLS/PERSONAL PROTECTION Control parameters Components with workplace control parameters Exposure controls Appropriate engineering controls Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Personal protective equipment Eye/face protection Safety glasses with side-shields conforming to EN166 Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it.
Body Protection impervious clothing, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a full-face particle respirator type N100 (US) or type P3 (EN 143) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Sigma - F4381 PHYSICAL AND CHEMICAL PROPERTIES Information on basic physical and chemical properties
Flammability (solid, gas) no data available
Other safety information no data available STABILITY AND REACTIVITY 10.1 Reactivity 10.2 Chemical stability 10.3 Possibility of hazardous reactions 10.4 Conditions to avoid 10.5 Incompatible materials 10.6 Hazardous decomposition products
Other decomposition products - no data available
Sigma - F4381 TOXICOLOGICAL INFORMATION 11.1 Information on toxicological effects Acute toxicity LD50 Oral - rat - 2.600 mg/kg Skin corrosion/irritation no data available Serious eye damage/eye irritation no data available Respiratory or skin sensitization no data available Germ cell mutagenicity no data available Carcinogenicity
This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification.
3 - Group 3: Not classifiable as to its carcinogenicity to humans (Furosemide)
Reproductive toxicity May cause congenital malformation in the fetus. Presumed human reproductive toxicant Specific target organ toxicity - single exposure no data available Specific target organ toxicity - repeated exposure no data available Aspiration hazard no data available Potential health effects Inhalation
May be harmful if inhaled. May cause respiratory tract irritation.
Ingestion
May be harmful if absorbed through skin. May cause skin irritation.
Signs and Symptoms of Exposure To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. Additional Information RTECS: CB2625000 ECOLOGICAL INFORMATION 12.1 Toxicity 12.2 Persistence and degradability 12.3 Bioaccumulative potential 12.4 Mobility in soil
Sigma - F4381
12.5 Results of PBT and vPvB assessment 12.6 Other adverse effects DISPOSAL CONSIDERATIONS 13.1 Waste treatment methods Product Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Contaminated packaging Dispose of as unused product. TRANSPORT INFORMATION 14.1 UN number 14.2 UN proper shipping name 14.3 Transport hazard class(es) 14.4 Packaging group 14.5 Environmental hazards 14.6 Special precautions for user REGULATORY INFORMATION
This safety datasheet complies with the requirements of Regulation (EC) No. 1907/2006.
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture 15.2 Chemical Safety Assessment OTHER INFORMATION Further information Copyright 2012 Sigma-Aldrich Co. LLC. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Corporation and its Affiliates shall not be held liable for any damage resulting from handling or from contact with the above product. See www.sigma- aldrich.com and/or the reverse side of invoice or packing slip for additional terms and conditions of sale.
Sigma - F4381
Special Purim Supplement Purim and Parody Like all the festivals of the Jewish calendar, Purim as we know it today is the product of a long history of development. Ostensibly a commemoration of national deliverance from danger, we should have expected solemn ceremonies of An exceptional passage in the "Bavli", the thanksgiving such as characterise Passover a
