Le tadalafil possède une affinité marquée pour la PDE5, mais épargne en grande partie les isoformes PDE1, PDE2 et PDE11, réduisant ainsi le risque d’effets extra-caverneux. L’action se traduit par une augmentation contrôlée de la circulation sanguine locale, indépendante des variations alimentaires. Sa pharmacocinétique repose sur une absorption digestive rapide, un métabolisme hépatique par CYP3A4 et une distribution tissulaire large. La biodisponibilité reste stable, et l’équilibre plasmatique est atteint en quelques jours lors d’administrations répétées. Les interactions cliniquement significatives surviennent avec les inhibiteurs puissants de CYP3A4 tels que le kétoconazole. Dans la littérature pharmacologique, acheter cialis 20 mg est souvent associé à des schémas d’utilisation basés sur la durée prolongée de son action.

Web 080 - 19 dec 10 - answers.doc

Solution to Crossword No: 080 by WEB
Copyright W. E. Butler, 2010
Dec 19, 2010
www.crosaire.paxient.com
1 A-WAY IN A MANGER
"duds" becomes "us" if we take out the Ds (NO DS) = MAN (WAY)GER is the word "WAY" written in the word 7 E-MIGREE
10 HOODLUM
After the East (E) gets a new "regime" (MIGREE) = boy-HOOD LUM-inary" hiding = HOODLUM: a gang 8 CHRISTMAS TREE
11 REDDI-S H
Organises "crimes" and "threats" = CHRISTMAS TREE: up Re-did "re-did" (REDDI) quietly (SH) = REDDISH: sort of 9 THE NUTCRACKER
12 I(DL)E
That looks like a soldier (THE NUTCRACKER) dancing at That is (I-E) around Donegal (DL) it's = IDLE: not working. 14 NE-W YEAR
If the "men" quit "TENE-men-T" we get TENET: the belief. The last half of ju-NE (NE) terribly "weary" (W-YEAR) = The heartless "GR-eml-IN" for = GRIN: a broad smile. 16 V-ERNE
At five (V) by the lough (ERNE) = VERNE: "I'm" often Even letters from "f-R-i-E-n-D-s" (R-E-D) are = RED: a 18 C(LE)AN
19 TINS -EL
Inside "can" (C-AN) I hear Ellie (LE) = CLEAN: get rid of "Isn't" changing (TINS) "the" Spanish (EL) = TINSEL: for 21 EL-D-EST
"The" French (LE) to take tea (T) = LET: allow. L (EL) D (D) "is" Latin (EST) for = ELDEST: first-born. 22 RE-CYCLE
East (EAST) Limerick (L) motorway (M) = ELM: a About (RE) to take your bike (CYCLE) and = RECYCLE: nightmare of a street? (As in "A Nightmare on Elm Street") 24 V(AU)LTED
23 AD-VENT
In the unsettled "veldt" (V-LTED) the gold (AU) = Commercial (AD) outlet (VENT) for = ADVENT: a 26 GRA-N(IT)E
25 MANGER
The Irish "love" (GRA) "it" in the "northeast" (N-IT-E) = MAN-a-GER without "a" = MANGER: word in AWAY IN 27 HUM-AN-E
To hum (HUM) a note below F (AN E) = HUMANE: kind. Left half of HAM-per = HAM: to be eaten with the turkey. 28 MUESLI
"Lime" and "US" bananas = MUESLI: nuts, oats and fruit. It starts t -o (T) hug (HUG) = THUG: HOODLUM. 30 GUR-US
The "rug" back (GUR) to us (US) to get = GURUS: they're It's "long for" (PINE) CHRISTMAS TREE perhaps (PINE). Thanks (TA) to Elsie (LC) = TALC: it's a powder. 34 ES -TO-NI-A
Turn southeast, 'SE', (ES) to Northern Ireland (TO NI) a (A) 35 S(U-I-C)IDE
In-side (S-IDE) you I see (U I C) for = SUICIDE: it's self-
36 ADESTE FIDELES
Broken "faded tiles see" = ADESTE FIDELES: carol. 2 WOO-L-LEN
To woo (WOO) the learner (L) Leonard (LEN) = "You'll", listen to it, and you'll hear = YULE: this Christmas. No (NUMBER) anaesthesiologist (NUMBER, one who "numbs").
5 MARK-ED
Between Matthew and Luke (MARK) and Edward (ED) it's

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