J. Barbara Nebe, Dr. Vice-Chair, Dept. of Cel Biology Address Center of Medical Research, Dept. of Cel Biology
Medical Faculty, University of Rostock18057 Rostock, GermanyTel./Fax: +49 (0)381 494 7771/7764
Curriculum Vitae
Vice Chair of the Dept. of Cel Biology, Center of Medical Research, Medical Faculty,University of Rostock
Habilitation, University of Rostock: Integrin receptors and their importance for cel adhesion and extracel ular matrix-interaction and cel signal ing – clinical aspects
Dissertation, University of Rostock: thesis title: Flow cytometric characteristics of epithelial cel s concerning integrin mediated interactions with extracel ular matrix molecules, summa cum laude
Dipl.-Ing. agr., University of Rostock: Principle investigations on hol ow fiber coatings with col agen I
Laboratory engineer, Center for Bioengineering, University of Rostock
Laboratory engineer for veterinary medicine and diagnostics (equivalent to Dipl.-Ing. (FH)
Awards and Notable Services
• Member of the Executive Committee of the German Society of Biomaterials, 2008-to date
• Equal Opportunity Commissioners, University of Rostock, Medical Faculty, 2008-to date
• Organizer Symposium Biomaterials-C „Functionalized Materials for Therapeutic Applications“, THERMEC‘2009 International Conference on Processing and Manufacturing of Advanced Materials, Berlin, 2009.
• Co-organizer of the international congress „Interface Biology of Implants“ (IBI) in Rostock-
• Organizer lecture „Biosystem-Material-Interaction“ University of Rostock, Interdisciplinary
• Co-organizer of the international congress „Interface Biology of Implants“ (IBI) in Rostock-
• Co-organizer E-MRS Fal Meeting, Symposium J „Surface Functionalization and activation of biomaterials“, Warschau/Poland, 2006.
• Co-organizer of the international congress „Interface Biology of Implants“ (IBI) in Rostock-
• Co-organizer of the congress of the German Society of Cel Biology in Rostock, 1999.
Award: Joachim-Jungius Price of the University of Rostock, awarded 1996.
Reviewer (on inquiry) for Biomaterials, Materials Science and Engineering, Biomedical Materials, Journal of Biomedical Materials Research, Part: A, International Journal of Materials, Acta Biomaterialia, Advanced Biomaterials, International Journal of Nanomedicine, BIOmaterialien, Materials Science and Engineering
Invited speaker (international congresses):
-Quebec, Canada 04.08.2011, THERMEC’2011-Tampere, Finnland 09 2011, ESB-Berlin, 28.08.2009, THERMEC’2009-Singapore, 26.06.2009, ICMAT 2009-Warschau, Polen 08.09.2006, E-MRS Fal Meeting 2006-Vancouver, Canada 07 2006, THERMEC’2006-Teneriffa, Spanien 03.08.2005, ICCE-12
DFG Projects
DFG GRK 1505/1 welisa: theme A-4: Analysis of initial adhesion mechanisms in dependence of chemical, topographical and electrical characteristics of implant surfaces2008-to date
DFG NE560/7-1, 7-2: Mathematical model ing of cel material interaction2008-to date
DFG NE560/3-1, 3-2, 3-3, 3-4: Priority program SPP 322 1100 Interface interactions and Biosystems2000-2006
DFG NE560/5-1, 5-2, 5-5: Adhesion inhibition of lens epithelial cel s to prevent Cataracta secundaria2001-2007
List of 10 most relevant publications
Matschegewski C, Staehlke S, Loeffler R, Lange R, Chai F, Kern D, Beck U, Nebe JB: Cel architecture―cel function dependencies on titanium arrays with regular geometry. Biomaterials 31 (2010) 5729-5740.
Kunz F, Bergemann C, Klinkenberg E-D, Weidmann A, Lange R, Beck U, Nebe JB: A novel modular device for 3-D bone cel culture and non-destructive cel analysis. Acta Biomater (2010) DOI: 10.1016/j.actbio.2010.03.015
Rebl H, Finke B, Rychly J, Schröder K, Nebe JB: Positively charged material surfaces generated by plasma polymerized al ylamine enhance vinculin mobility in vital human osteoblasts. Advanced Biomat (2010) accepted.
Schröder K, Finke B, Lüthen F, Jesswein H, Ihrke R, Ohl A, Weltmann K.-D., Diener A, Rychly J, Nebe JB: Similarities between plasma amino functionalized PEEK and titanium surfaces concerning enhancement of osteoblast cel adhesion. Journal of Adhesion Science and Technology JAST 24 (2010) 905–923. Nebe JB, Mueller L, Luethen F, Ewald A, Bergemann C, Conforto E, Muel er FA: Osteo- blastic adhesion and function response to biomimetical y altered titanium surfaces. Acta Biomater 4 (2008) 1985-1995.
Nicula R, Lüthen F, Stir M, Nebe B, Burkel E: Spark plasma sintering synthesis of porous nanocrystal ine titanium al oys for biomedical applications. Biomol Eng 24/5 (2007) 564-567.
Finke B, Luethen F, Schroeder K, Mueller PD, Bergemann C, Frant M, Ohl A, Nebe JB: The effect of positively charged plasma polymerization on initial osteoblastic focal adhesion on titanium surfaces. Biomaterials 28/30 (2007) 4521-4534.
Lüthen F, Bulnheim U, Mül er P, Rychly J, Jesswein H, Nebe B: Influence of manganese ions on cel ular behavior of human osteoblasts in vitro. Biomol Eng 24/5 (2007) 531-536. Nebe B, Lüthen F, Lange R, Beck U: Interface interactions of osteoblasts with structured titanium surfaces and their mathematical correlation. Macromol Biosci 7 (2007) 567-578.
[10] Lüthen F, Lange R, Becker P, Rychly J, Beck U, Nebe JB: The influence of surface roughness of titanium on β1- and β3-integrin adhesion and the organization of fibronectin in human osteoblastic cel s. Biomaterials 26 (2005) 2423-2440.
Research Monographs & Textbooks Nebe JB, Lüthen F: Integrin- and Hyaluronan-mediated cel adhesion on titanium – Hyaluronan- mediated adhesion. In: Metal ic Biomaterial Interactions, Eds.: J. Breme, C.J. Kirkpatrick, R. Thul , WILEY-VCH, ISBN 978-3-527-31860-5, 2008, p. 179-182.
Briese V, Abarzua S, Richter D-U, Piechulla B, Nebe JB: Molecular and cel biological investigations to the mode of action of established and potential phytoestrogens for the development of strategies in the prevention and therapy of cancer. In: Estrogens: Production, Functions and Applications, Hrsg. James R. Bartos (Editor). 2009, Nova Science Publishers, Inc., New York, ISBN 978-1-60741-086-7. p. 1-53. Research Summary (main focus)
Cel biological investigations to understand the topographical and chemical influences of the biomaterial surface on cel adhesion structures, cel signal ing, cel growth, intracel ular apoptotic cascades, adhesion receptor expression, cel function (transcription and translation level of proteins), cel differentiation.
Experiences in cross-disciplinary research on the research field of biosystem-material-interaction.
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