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Cher patient,

TRETINOIN

Dear patient,
Please read the following instructions carefully. They contain important information
about the use of this medicine. If you have any further questions, please ask your
doctor or pharmacist.
Information about TRETINOIN
TRETINOIN is available as 0.1%, 0.05%, and 0.025% viscous topical solutions. TRETINOIN
is a form of vitamin A used for the treatment of mild to moderately severe acne.
TRETINOIN 0.05% is also indicated for the treatment of keratinisation disorders and warts.
The way to use TRETINOIN
Use as directed by your physician. Do not discontinue the treatment without consulting your
doctor. The usual recommended dose is:
- Attack treatment for 2 to 3 months The solution is applied once daily, in the evening, to the skin where acne lesions appear, using enough to cover the entire affected area lightly. Applications are adapted according to the skin's reactions. During the first and second week, the application may cause a transient feeling of warmth or slight stinging. During the second and third week of therapy, an exacerbation of acne lesions may occur. This is due, in part, to the action of the medication on deep lesions and should not be considered a reason to discontinue therapy. Therapeutic results should be noticed after 2 to 3 weeks but more than 6 weeks of therapy may be required before definite beneficial effects are seen. - Maintenance treatment for several months The solution is applied 2 to 3 times per week. -Treatment should be progressively stopped. TRETINOIN 0.1% is more adapted for use on the back. For the treatment of keratinisation disorders or warts (TRETINOIN 0.05%):
Frequency of applications varies according to the affection. The average daily dose is 1 to 2
applications.
Application
First, wash with a mild soap and dry your skin gently. Apply the solution by a cotton swab or
with your fingertips, avoiding eyes, nostrils, lips, mucous membranes, open sores, or irritated
skin. Wash your hands afterwards.
In case of overdose
An overdose of this medication is unlikely to occur. If medication is applied excessively, no
more rapid or better results will be obtained and marked redness, peeling, or discomfort may
occur. If you do suspect an overdose, or if tretinoin topical has been ingested, inform your
doctor at once and seek emergency medical attention. General measures should be
adopted.
In case of missed dose
Apply the missed dose as soon as you remember unless the next application is near. Go on
applying the next scheduled dose as directed. Do not apply a double dose at once.
Contraindications
It should not be used in case of hypersensitivity to any of the components.
Precautions
Before starting therapy, it is preferred to apply the solution on a reduced area of the Avoid contact with eyes, mouth, nostrils, mucous membranes, irritated skin or open sores. If contact occurs rinse it off with water. Avoid products that can increase skin irritation such as abrasive soaps or astringent skin cleansers (perfumed or alcoholic products). Avoid exposure to sunlight while using this solution. Use a sunscreen and wear protective clothing when exposure to the sun is unavoidable. Patients with sunburn should not use the product until fully recovered. Avoid using this medication if you are pregnant or nursing an infant. Association with other medications
Please inform your doctor if you are using any other medication.
You should avoid preparations that may dry or irritate your skin.
Side effects
Topical use may induce local erythema and peeling at the site of application during the early
days of treatment. Should the effects become excessively troublesome, consult your doctor,
the medication dosing frequency should be adjusted. People having a fine skin or blond hair
are more susceptible to these reactions.
A transient exacerbation of acne may be observed.
Temporary hyper- or hypopigmentation has been observed with repeated application of
tretinoin solution.
Storage
Store at controlled room temperature (up to 30°C), protected from sunlight and humidity,
beyond the reach of children.
The expiry date is printed on the pack; don’t use this medicine after this date.
Pack presentation
TRETINOIN 0.1% viscous topical solution, bottle of 50ml.
TRETINOIN 0.05% viscous topical solution, bottle of 50ml.
TRETINOIN 0.025% viscous topical solution, bottle of 50ml.
Issue date: 11/2003

Source: http://www.medipharlabs.com/attachments/article/184/TRETINOIN.pdf

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