Le tadalafil possède une affinité marquée pour la PDE5, mais épargne en grande partie les isoformes PDE1, PDE2 et PDE11, réduisant ainsi le risque d’effets extra-caverneux. L’action se traduit par une augmentation contrôlée de la circulation sanguine locale, indépendante des variations alimentaires. Sa pharmacocinétique repose sur une absorption digestive rapide, un métabolisme hépatique par CYP3A4 et une distribution tissulaire large. La biodisponibilité reste stable, et l’équilibre plasmatique est atteint en quelques jours lors d’administrations répétées. Les interactions cliniquement significatives surviennent avec les inhibiteurs puissants de CYP3A4 tels que le kétoconazole. Dans la littérature pharmacologique, acheter cialis 20 mg est souvent associé à des schémas d’utilisation basés sur la durée prolongée de son action.
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Netta ORSoprano
Netta Or was born in Israel, she studied at the Music High School in Cologne with Prof. Leisenheimer and joined master classes of Kurt Moll and Joan Dorneman, already with ten years she sang smaller roles like 1° Knabe in „Zauberflöte“ and appeared in „Macbeth“ at the theatre of Aachen. First guest contracts brought her to the theatre in Bonn as Serpina in „Serva Padrona“ by Pergolesi, to Montepulciano as Despina and to Hagen for „Hänsel und Gretel“. Till 2009 she was engaged in Düsseldorf, where she was heard as Zerlina, Musette, Marzelline, Nuri, Gretel, Donna Elvira, Konstanze and Adina. She sang concerts at the Schlosskonzert in Brühl, in Bayreuth, at Festspielhaus St. Pölten, in Nurnberg baroque concerts with Mo. Märkl, in Bonn „Messias“, in Cologne and Paris „Johannespassion“ and in SanSebastian Mozart concerts. She sang in Karlsruhe Alceste in Händel’s pasticcio „Die Plagen“, in Cologne and at Théâtre des Champs Elysées in Paris „Johannespassion“, in Potsdam Aspasia in „Orfeo“ of Graun, Iöle in „Hercules“ by Händel, in Göttingen Händel’s „Jephta“, in Utrecht Graun’s „Orfeo“ and in Klagenfurt and Kassel „Italiana in Algeri“. Netta Or made her successful debut as Aspasia in „Mitridate“ at the Festival in Salzburg with Mo. Minkowski, she got engaged by the Festival in Schwetzingen for Scarlatti’s „Telemaco“ with Mo. Hengelbrock, by Dublin for Rosemene in Händel’s „Imeneo“ and by Madrid and Bremen for „Mitridate“. She sang her first Donna Anna at Festival Klosterneuburg/Vienna (with new contract for 2011 as Countess in „Nozze di Figaro“), a role she sang also in Düsseldorf and Amsterdam, as Donna Elvira she was heard in Essen and with „Mitridate“ in Budapest. 2009/2010 she sang Fulvia in Händel’s “Ezio“ at the Festival in Schwetzingen (Cremonesi Krämer), Fiordiligi in St. Gallen, Donna Anna in Leipzig and Singapore, „Johannespassion“ in Hannover, „Faramondo“ (Händel) in Paris as well as concerts with the ensemble Mattheus with Mo. Spinos, „Stabat Mater“ by Pergolesi with Mo. Cremonesi in Den Haag and Amsterdam. 2011 she was singing Bach/Pergolesi concerts in Milan, Musette in Verbier, Countess in „Nozze di Figaro“ in Klosterneuburg/Vienna, Pergolesi’s „Stabat Mater“ in Amsterdam, „Messa Cecilia“ of Scarlati in Ascona and „Messias“ with Mo. Dantone in Ravenna and Amsterdam. 2011/12 she is singing „Romolo ed Ersilla“ of Hasse in Innsbruck, Adele in Nancy, „Temistocle“ at the „Mozartwochen“ in Mannheim and Schwetzingen, she makes her debut as Violetta in a „Traviata“ production in Coburg, where she is singing in summer 2012 also Donna Anna. 2012/13 she will be heard as Alcina in Stuttgart, as Konstanze at Volksoper Vienna, as Foleville in “Viaggio a Reims” in Hannover, with Carmina Burana in Cologne, as Rosalinde in Salzburg and Essen, 2013/14 she will sing Donna Anna in St. Gallen, "Il Battista" (Caldera) in Cologne, Giovanna d'Arco in Bielefeld and in summer 2014 "Leocippo" from Hasse at Festival in Schwetzingen, 2014/15 she will be heard as Konstanze in St. Gallen. Ms. Or has recorded on CD „Demofoonte“, „Ezio“ and „Mitridate“ (Decca).
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