Le tadalafil possède une affinité marquée pour la PDE5, mais épargne en grande partie les isoformes PDE1, PDE2 et PDE11, réduisant ainsi le risque d’effets extra-caverneux. L’action se traduit par une augmentation contrôlée de la circulation sanguine locale, indépendante des variations alimentaires. Sa pharmacocinétique repose sur une absorption digestive rapide, un métabolisme hépatique par CYP3A4 et une distribution tissulaire large. La biodisponibilité reste stable, et l’équilibre plasmatique est atteint en quelques jours lors d’administrations répétées. Les interactions cliniquement significatives surviennent avec les inhibiteurs puissants de CYP3A4 tels que le kétoconazole. Dans la littérature pharmacologique, acheter cialis 20 mg est souvent associé à des schémas d’utilisation basés sur la durée prolongée de son action.

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L A N C A S H I R E A N D C H E S H I R E . J o h n P a u l R y l a n d s , F . S . A . , Highfields, B id s t o n R o a d , Birkenhead, Sir G e o r g e J. A r m v t a g e , Bart., D .L ., F .S.A., Kirklees Park, B rig- Lieut.-Col. H e n r y F i s h w i c k , F.S.A ., T he Heights, Rochdale, Vice- H e n r y B r i e r l y , I ! . A., 26 Swinley Road, Wigan.
W i l l i a m F a r r e r , D .Litt., H all Garth, C a rnforth.
R o b e r t G l a d st o n e, Jun., H . C . L . , M . A . , V ale R o a d , W oolton, near W m. F e r g u s s o n I r v i n e , M.A., F .S .A ., 56 Park Road South, B irken­ Colonel J o h n P a r k e r , C.B., D .L., F .S .A ., Brow sholme, Clitheroe.
W . D. P in k, Winslade, Lowton, Newton-le-W illows.
R . D. R A D C L IF F E , M.A., F .S .A ., Old Swan, Liverpool.
C h a r l e s W . S u t t o n , M .A., Free R eference Library, M anchester.
W m . A s h t o n T o n g e , S t a n e c ly ff e , D i s ley.
F. C. B e a z l e y , F.S .A ., 27 Shrewsbury Road, Oxton, Birkenhead.
R o n a l d S t e w a r t - B r o w n, M .A., F .S .A ., 34 Castle Street, Liverpool.
A N D NOW P R E S E R V E D IN T H E P R O B A T E C O U R T AT F r o m 1 7 9 3 t o 1 8 1 2 .
A L I S T O F T H E W I L L S P R O V E D I N T H E L ieut.-Col. H E N R Y F I S H W I C K , F . S .A.
T i i e R e c o r d S o c i e t y .
T h e twenty-th ird volume of the Society’s publications, which a p ­ peared in 1 8 9 1 , contains a List of the I^ancashire W ills proved at Lancaster from 1 748 to the end o f 179 2, and of H a lt o n W ills T h e present volume continues the list do wn to 1 8 1 2 , the latest date allowed for present publication.
T h e Wills o f the five Western Deaneries of the A rc h d e a c o n r y of Richm ond ceased to be proved at Lancaster in 18 5 7 (see Introductions to Vols. X , X I I I , and X X I I 1).
T h e Wills in this volume are at Lancaster, where all the Lancashire Wills proved in the Archdeaconry of R ic h m o n d since date were, in 18 74 , moved to Somerset House. application by the Yorkshire Archaiological Society, the Wills relating to the Eastern Richm ond Deaneries o f B o ro u g h bridge, Catterick, and Richm ond were transferred from S om erse t H o u s e to the District Probate Registry at York. application it was suggested that this Society should apply for the transfer, to Lancaster, of the Lancashire portion o f the Richmond Wills at Somerset House, but the C o u n c il declin ed to do so as it was considered that the documents were more conveniently accessible in London (where there is a skille d body o f professional searchers and transcribers) than at Lancaster. In the early part of the present year the H onorary S ecretary was informed that it was proposed to remove the Lancash ire portion o f the R ichmond Wills to York (where the Y orksh ire portion had already gone), and upon inquiry at the Principal Probate Registry it was found that the removal to Y ork of the remaining R ic h mond Wills had been authorised but not yet c a rried out. Strong protests were at once made by this Society and other Archaeological Societies, to the President of the Probate D iv ision and also to the R oyal Com m issio ners now sitting to inquire into the custody and preservation o f public records, and it is satisfactory to be able to state that in c o n se q u e n c e o f these protests it was decided in February last that the R ich m o nd Wills, other than those o f the Y orksh ire D e a n erie s, should T h is volume also includes a list o f the Wills proved within the Peculiar of the M anor of H alto n for the same p erio d. are very few, and since the death o f William Bradshaw , Esq. (L ord o f the M anor o f H alton), in 1 8 1 5, no Will has been T h e Society is indebted to the President o f the P ro b a te Divi­ sion of His Majesty’s H igh Court o f Ju s t ic e fo r permission to permit these indices, and I must also personally th ank B. D. Adams, Esq., the Distric t Registrar at L a n c aster, for kind E X P L A N A T I O N OF T H E A B B R E V I A ­ A d . means an administration but no Will. A.W . signifies an Administration with Will annexed.
T u o n or C u r o n B o n d signifies a B ond given for the guardian­ ship o f the infant child or children of the deceased.
“ A ,” “ F , ” “ K , ” “ L , ” at the end of the description, indicate the Deanery in which the papers are filed (Amounderness,

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