Pharmaceutical Substances Preface to the Online Edition Update August 2006 The online version of Pharmaceutical Substances is now 3 years old and finds steadily increasing reception. This is due to its topicality by biannual updates with new entries, corrections and additions and the versatile search functions. The recent update has brought 10 new drug substances and more than 40 revised monographs of important drugs (e.g. Atorvastatin, Beclometasone, Citalopram, Ciprofloxacin, Efavirenz, Fluticasone, Imipenem, Oseltamivir, Oxcarbazepine, Rosuvastatin, Ubidecarenone). In many cases the synthesis processes had to be complemented or changed. The ACS Journal “Organic Process Research and Development” is giving many valuable hints for the industrially applied synthesis processes. The patent and literature citations for important drugs have been complemented and we began to name the “Key intermediates” after the synthesis schemes. In a few cases, in which we had reliable information, we also mentioned the bulk drug manufacturers (e.g. Imipenem, Ubidecarenone). With regard to the patent literature a new trend is quite remarkable: more and more “Generics companies” (e.g. Teva, Hexal, Ranbaxy, Dr.Reddy´s et al.) are filing patents for improvements of late synthesis steps and polymorphic forms, but also new substance patents. Where it seemed useful to us we included such patent references. The list of abbreviations has been revised and it is in line with the corresponding lists of the ACS journals. Mergers and Acquisitions in the Pharmaceutical Industry are steadily ongoing. As a consequence many familiar and famous company names disappeared (e.g. Aventis, Boehringer Mannheim, Fujisawa, Hoechst, ICI, Knoll, Pharmacia, Squibb, Upjohn, Yamanouchi, Zeneca), new company names appeared (e.g. Actelion, Astellas, AstraZeneca, Daiichi-Sankyo), and many product brands have also been changed. This requires countless “corrections”, which have to be made in time. The authors try hard to be up-to-date in this respect. The authors are deeply indebted to all collaborators who contributed to the development of the online version and its updates. We are very grateful to the colleges of the FIZ CHEMIE BERLIN, namely Ingo Adamczyk (coordination), Martin Hohlberg (graphics), Ulrich Quandt (data collection) and René Deplanque (Managing Director), InfoChem, namely Josef Eiblmaier (Project Manager), Josef Oberckal (software programming), Jakob Ruhdorfer (data processing), and Peter Löw (Managing Director), and, of course, Georg Thieme Verlag, namely Thomas Krimmer (Marketing Manager Thieme Chemistry) and Klaus Köberlein (coordination of data transfer and building the full text index and the html pages). They all did an excellent job! Frankfurt a. M., July 2006
Créé personnellement pour: Sandra Mariani FOOTBALL SPORTS 31 Elfsborg Le Fola sort de sa première campagne européenne depuis 1973 la tête bien haute. championne de Suède dans quelques mois, il a décroché un nul plus que mérité. Problème derrière le genou pour Souto petites journées, a réalisé des miracles. Le meneur de jeu cap-verdien du Fola, Ronny Souto, était déjà
RESPIRATORY DISTRESS Gregory Gilbert, MD EMS Medical Director Louise Rogers Information Needed: History: fever, sputum production, medications (bronchodilators, diuretics) asthma, COPD, exposures (allergens, toxins, fire/smoke), trauma (blunt/penetrating) Recent use of sildenafil (Viagra ) or other erectile dysfunction medications Symptoms: chest pain, shortness of breath, c