Animal research highlights a therapeutic potential of cannabinoids for the treatment of depression Regina A. Mangieri Department of Pharmacology, The University of Texas at Austin, Austin, TX 78712, USA Abstract Long known for their mood altering effects, cannabinoids are currently under investigation for their therapeutic potential in the treatment of depression. Findings from multi
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Purgopil_en_plPACKAGE LEAFLET: INFORMATION FOR THE USER PURGO-PIL 10 mg, gastro-resistant tablets
Read all of this leaflet carefully because it contains important information for you.
This medicine is available without prescription. However, you still need to take Purgo-pil carefully to get the best Keep this leaflet. You may need to read it again. Ask your pharmacist if you need more information or advice. - You must contact a doctor if your symptoms worsen or do not improve after 4 to 5 days. If any of the side effects gets serious, or if you notice any side effect not listed in this leaflet, In this leaflet:
What Purgo-pil is and what it is used for? 1. WHAT PURGO-PIL IS AND WHAT IT IS USED FOR?
Purgo-pil is a medicine that promotes the stool (laxative). - The short term treatment of the symptoms of bowel blockage (constipation). - Facilitation of bowel motion in case of haemorrhoids. - Evacuation of the bowel content before certain operations or examinations of the gastro-intestinal system. 2. BEFORE YOU TAKE PURGO-PIL.
Do not take Purgo-pil
If you are allergic (hypersensitive) to bisacodyl or any of the other ingredients of Purgo-pil. If you have stomach-ache of which the cause is unknown. In case of an inflammation of the large intestine. In case of mechanical blocking of the intestine. If you are suffering from serious dehydration. Take special care with Purgo-pil
Purgo-pil should not be used chronically. It is recommended not to take Purgo-pil for a period longer than 7 consecutive days. If daily use of medicines that promote the stool (laxatives) is necessary, the cause of the bowel blockage (constipation) should be investigated. PACKAGE LEAFLET: INFORMATION FOR THE USER Purgo-pil should only be administered to children on medical advice. Medicines that promote the stool (laxatives) should only be prescribed for children in exceptional circumstances. If you are elderly or have a heart condition or if you take medication which may cause a certain type of arrhythmias (torsades de pointes) or if you suffer from poor kidney function, it may be advisable in some Excessive or long-term use may cause a lowered potassium level in the blood (hypokalaemia) which could lead consequently to cardiac arrhythmia and renewed bowel blockage (constipation). Cases of dizziness and/or sudden loss of consciousness have been reported in patients taking bisacodyl (the active substance of Purgo-pil). Analysis of these cases suggests that they are not necessarily due to the fact that patients had taken bisacodyl, but rather due to bowel blockage (constipation) itself. In case of bowel blockage a sudden loss of consciousness (defecation syncope) can occur due to straining during defecation. In addition, bowel blockage can be related with abdominal pain. This abdominal pain can cause sudden and transient loss of consciousness (vasovagal response). If you are using other drugs as well. Please also read the section headed: “Taking other medicines". Consult your doctor if any of these aforementioned warnings apply to you, or if this has been the case in the Taking other medicines
Please tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription. The action of water tablets (diuretics) and products derived from purple foxglove (digitalis products) can be influenced by abuse of this medicine. When you use medicines against heartburn (antacids), such as bicarbonate, a 2-hour interval should be observed between taking Purgo-pil and these drugs. When you take medicines that can cause a certain type of arrhythmias (torsades de pointes) you should be prudent since the risk for these arrhythmias (torsades de pointes) is elevated when the potassium level in the blood is lowered (hypokalaemia) Taking Purgo-pil with food and drink
An interval of 2 hours must be maintained between the taking of Purgo-pil and of dairy products. Pregnancy and breast-feeding
Ask your doctor or pharmacist for advice before taking any medicine. It is not recommended taking Purgo-pil in the first three months of pregnancy. Although the active substance, bisacodyl, is not excreted in breast milk, it should only be used during breastfeeding if prescribed by a doctor. Driving and using machines
Important information about some of the ingredients of Purgo-pil
This medicine contains lactose. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product. PACKAGE LEAFLET: INFORMATION FOR THE USER 3. HOW TO TAKE PURGO-PIL?
Always take Purgo-pil exactly as your doctor has told you. You should check with your doctor or pharmacist if Short term treatment for bowel blockage (constipation): Adults and children over 10 years: Swallow the tablets with a little water without chewing them. The effect will be noticeable after approximately 8 hours. If the tablets are taken at bedtime, bowel emptying will occur in the morning. Once the desired effect has been achieved, you should gradually increase the period of time in between taking the tablets (take once every 2 days, then every 3 days, etcetera) in order to prevent habituation. The chronic use of this drug should be avoided. You should not take Purgo-pil for longer than 7 days without consulting your doctor. The use of medicines that promote the stool (laxatives) should only be seen as an additional measure to adapted life hygiene namely a high-fibre diet, sufficient fluid intake and physical exercise. In preparation for an operation or examination: If you take more Purgo-pil than you should
If you have taken too much Purgo-pil, contact your doctor, your pharmacist or the Anti-Poison centre Symptoms: diarrhoea, abdominal cramps, severe loss of electrolytes (e.g. potassium), dehydration. Treatment: vomiting may be induced immediately after a patient has taken Purgo-pil, or gastric lavage may be performed to counter the intake (absorption). Restoration of fluid and electrolyte balance may be necessary, particularly in elderly patients and children. Administration of medicines that prevent cramps (spasmolytic drugs) can prove beneficial. If you forget to take Purgo-pil
Do not take a double dose to make up for a forgotten tablet. If you stop taking Purgo-pil
If you have any further questions on the use of this product, ask your doctor or pharmacist. 4. POSSIBLE SIDE EFFECTS.
Like all medicines, Purgo-pil can cause side effects, although not everybody gets them. Possible side effects that occasionally appear are: abdominal cramps, abdominal pain, colic and Allergic reactions including rare cases of swelling (angio-oedema) and serious allergic reactions (anaphylactic reactions), have been reported in patients taking bisacodyl. Abuse may cause irritation (tingling) and potassium deficiency and, in the long run, “lazy” bowels. If any of the side effects gets serious, or if you notice any side effects not listed in this leaflet, please tell your PACKAGE LEAFLET: INFORMATION FOR THE USER 5. HOW TO STORE PURGO-PIL?
Keep out of the reach and sight of children. Store at room temperature. Do not use Purgo-pil after the expiry date which is stated on the blister/the carton after “EXP”. The first two figures indicate the month, the next two or four figures the year. The expiry date refers to the last day of that month. 6. FURTHER INFORMATION.
What Purgo-pil contains
The active substance is bisacodyl 10 mg. The other ingredients are lactose, cellulose microcrystalline and magnesium stearate. Coating: methacrylic acid-ethyl acrylate copolymer (1:1) 30% dispersion, methacrylic acid-methyl methacrylate copolymer (1:1) 12,5% solution, talc, titanium dioxide, macrogol 6000, simethicone 30% What Purgo-pil looks like and contents of the pack
Box of 12, 30 of 90 gastro-resistant tablets in a blister. Marketing authorisation holder and manufacturer
Laboratoria QUALIPHAR N.V./S.A. - Rijksweg 9 - 2880 BORNEM - Belgium Marketing authorisation numbers: BE015924
This leaflet was last approved in 07/2012.
Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John's wort): randomised controlled double blind non-inferiority trial versus paroxetine A Szegedi, R Kohnen, A Dienel and M Kieser 2005;330;503-; originally published online 11 Feb 2005; BMJ doi:10.1136/bmj.38356.655266.82 Updated information and services can be found at: References This article