SAFETY DATA SHEET
according to Regulation (EU) No. 1907/2006
1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND OF THE COMPANY/UNDERTAKING
: Tetracycline hydrochloride
The Old Brickyard NEW ROAD, GILLINGHAM Dorset SP8 4XT UNITED KINGDOM
2. HAZARDS IDENTIFICATION Risk advice to man and the environment Irritating to eyes, respiratory system and skin. 3. COMPOSITION/INFORMATION ON INGREDIENTS Tetracycline hydrochloride 64-75-5 200-593-8 4. FIRST AID MEASURES General advice Consult a physician. Show this safety data sheet to the doctor in attendance. If inhaled If breathed in, move person into fresh air. If not breathing give artificial respiration Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Sigma - T7660 www.sigma-aldrich.com 5. FIRE-FIGHTING MEASURES Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Special protective equipment for fire-fighters Wear self contained breathing apparatus for fire fighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Personal precautions Use personal protective equipment. Avoid dust formation. Avoid breathing dust. Ensure adequate ventilation. Environmental precautions Do not let product enter drains. Methods for cleaning up Pick up and arrange disposal without creating dust. Keep in suitable, closed containers for disposal. 7. HANDLING AND STORAGE Handling Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Provide appropriate exhaust ventilation at places where dust is formed. Normal measures for preventive fire protection. Storage Store in cool place.Keep container tightly closed in a dry and well-ventilated place. 8. EXPOSURE CONTROLS / PERSONAL PROTECTION
Contains no substances with occupational exposure limit values.
Personal protective equipment Respiratory protection Where risk assessment shows air-purifying respirators are appropriate use a dust mask type N95 (US) or type P1 (EN 143) respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Hand protection Handle with gloves. The selected protective gloves have to satisfy the specifications of EU Directive 89/689/EEC and the standard EN 374 derived from it. Eye protection Safety glasses Skin and body protection Choose body protection according to the amount and concentration of the dangerous substance at the work place. Hygiene measures Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance Safety data
Sigma - T7660 www.sigma-aldrich.com 10. STABILITY AND REACTIVITY Storage stability Stable under recommended storage conditions. May discolor on exposure to light. Materials to avoid Strong oxidizing agents Hazardous decomposition products Hazardous decomposition products formed under fire conditions. Carbon oxides, nitrogen oxides (NOx), Hydrogen chloride gas 11. TOXICOLOGICAL INFORMATION Acute toxicity Irritation and corrosion Sensitisation
Prolonged or repeated exposure may cause allergic reactions in certain sensitive individuals.
Chronic exposure
This product is or contains a component that is probably not carcinogenic based on its IARC, ACGIH, NTP, or EPA classification.
Signs and Symptoms of Exposure
phototoxic reactions, Gastrointestinal disturbance, yellowing of teeth, reduced mineralization
Potential Health Effects Inhalation
May be harmful if inhaled. Causes respiratory tract irritation.
May be harmful if absorbed through skin. Causes skin irritation.
Ingestion Target Organs 12. ECOLOGICAL INFORMATION Elimination information (persistence and degradability) Ecotoxicity effects
LC50 - Salvelinus namaycush - 220 mg/l - 96 h
Sigma - T7660 www.sigma-aldrich.com Further information on ecology 13. DISPOSAL CONSIDERATIONS Product Observe all federal, state, and local environmental regulations.Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber.
Contaminated packaging Dispose of as unused product. 14. TRANSPORT INFORMATION ADR/RID Not dangerous goods IMDG Not dangerous goods IATA Not dangerous goods 15. REGULATORY INFORMATION Labelling according to EC Directives
Irritating to eyes, respiratory system and skin.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
16. OTHER INFORMATION Further information Copyright 2007 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Co., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale.
Sigma - T7660 www.sigma-aldrich.com
FACTSHEET NHS Drug Expenditure – Top 10 When the NHS was launched in 1948 it had a budget of £437million (roughly £9billion at today’s value). In 2008/9 it received over 10 times that amount (more than £100billion). This equates to an average rise in spending over the full 60-year period of about 4% a year once inflation has been taken into account. However, in recent years investm