Optimal Versus Suboptimal Treatment for HIV-InfectedPregnant Women and HIV-Exposed Infants inLehman et al1 study in this issue of J Acquir Immune Defic Syndr uses a randomizedtrial design to compare the emergence of viral resistance in women receiving highly activeantiretroviral therapy (HAART) compared with zidovudine (ZDV) plus single-dosenevirapine (sdNVP) on the emergence of viral resista
Australian people can buy antibiotics in Australia online here: http://buyantibioticsaustralia.com/ No prescription required and cheap price!
The evidence on emergency treatment of arrhythmias was reviewed and the only change was the addition of procainamide as possible therapy for refractory supraventricular tachycardia (SVT). Unstable VT
Consensus on Science
There is insufficient evidence to support or refute the efficacy of electric therapy over drug therapy or the superiority of any drug for the emergency treatment of unstable VT in the pediatric age group. In 2 LOE 5 adult case seriesearly electric cardioversion was effective for treatment of unstable VT. In 4 small LOE 4 pediatric case serieamiodarone was effective in the management of VT. One prospective randomized multicenter safety and efficacy LOE 2 trial evaluating amiodarone for the treatment of pediatric tachyarrhythmifound that 71% of children treated with amiodarone experienced cardiovascular side effects. Both efficacy and adverse events were dose-related. Treatment Recommendations
It is reasonable to use synchronized electric cardioversion as the preferred first therapy for pediatric VT with hypotension or evidence of poor perfusion. If drug therapy is used to treat unstable VT, amiodarone may be a reasonable choice, with careful hemodynamic monitoring performed during its slow delivery. Drugs for Supraventricular Tachycardi
Consensus on Science
Twenty-two LOE 4 studies in infants and childredemonstrated the effectiveness of adenosine for the treatment of hemodynamically stable or unstable SVT. One LOE 4 studand 4 larger LOE 5 studies involving teenagers and adulalso demonstrated the efficacy of adenosine, although frequent but transient side effects were reported. One LOE 2 studshowed highly successful (approximately 90%) treatment of SVT in infants and children using adenosine or verapamil and superiority of these drugs to digitalis (61% to 71%). One LOE 5 randomized prospective adult studand 1 LOE 5 meta-analysis, primarily involving adults but including some childrendemonstrated the effectiveness of verapamil and adenosine in treating SVT and highlighted the cost-effectiveness of verapamil over adenosine. One LOE 4 randomized, prospective studand 15 LOE 4 small case series and observational studies in infants and childreshowed that amiodarone was effective in the treatment of supraventricular tachyarrhythmias. Generalization to pediatric SVT treatment with amiodarone may be limited, however, since most of these studies in children involved postoperative junctional tachycardia. Rare but significant side effects have been reported in association with rapid administration of amiodarone. Bradycardia and hypotension were reported in 1 prospective LOE 4 study cardiovascular collapse was reported in 2 LOE 5 case reportsand polymorphic VT was reported in 1 small LOE 4 case seriesOther LOE 5 case reports describe late side effects of pulmonary toxiciand hypothyroidism In 1 LOE 2 pediatric comparison control studprocainamide had a significantly higher success rate and an equal incidence of adverse effects when compared with amiodarone for treating refractory SVT. In 5 LOE 4 observational studieand 5 LOE 5 case reporprocainamide effectively suppressed or slowed the rate in children with SVT. A wide variety of arrhythmias were studied, including ectopic atrial tachycardia, atrial flutter, and orthodromic reciprocating tachycardia. In LOE 5 studies in childrenadultsand animalshypotension from procainamide infusion resulted from vasodilation and not decreased myocardial contractility. Initial observational LOE 4 reporand 1 LOE 4 case seriedescribed successful treatment of pediatric SVT with verapamil. However, multiple small LOE 4 case serieand LOE 5 case repordocumented severe hypotension, bradycardia, and heart block causing hemodynamic collapse and death following IV administration of verapamil for SVT in infants. Two small LOE 4 pediatric case seriedescribed esmolol and dexmedetomidine in the treatment of SVT. Treatment Recommendations
For infants and children with SVT with a palpable pulse, adenosine should be considered the preferred medication. Verapamil may be considered as alternative therapy in older children but should not be routinely used in infants. Procainamide or amiodarone given by a slow IV infusion with careful hemodynamic monitoring may be considered for refractory SVT.
Revisions to Product Labeling [These changes should be made to the box warning at the beginning of the package insert.] DRUG NAME Suicidality and Antidepressant Drugs Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other ps