CURRICULUM VITAE CHIARA CATELANI Esperienze di Studio di Danza 1977-1987 Centro Studi Danza di Firenze Studi di danza classica accademica con Lilia Bertelli, B. Baer, Cristina Bozzolini . 1983 Imago-Lab- Studi di danza contemporanea (tecnica NicKolais) con S.Bucci. Stages estivi : 1981-1982 Festival di Nervi- stages di danza classica con M. Fusco, R.Nunez, Lee, J.Garcia . 1
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Kein folientitelTesting the effectiveness of
health care products
against viral infections
Inhibition of viral neuraminidase:
comparison of products with
Relenza ® /Tamiflu®
VivaCell Biotechnology GmbH
Is your product a neuraminidase inhibitor?
Acting in the same line like Relenza ®/Tamiflu® ?
The risks stemming from new, increasingly aggressive virus generations, such as birdand swine flu virus, demand the search for novel agents/products protecting from furthervirus infections and outbreak of epidemies.
Viral neuraminidase is involved in virus-cell interactions; hydrolysis of terminal sialic acidresidues located host cell receptors is instrumental in the penetration of virus particlesthrough the mucus membrane of the respiratory tract and release of virions from infectedcells [1-3]. Consequently, neuraminidase inhibitors such as zanamivir, (Relenza) oroseltamivir(Tamiflu) have been succesfully administerd in the control of influenzainfections.
In order to respond to the increasing demand for new inhibitors, VivaCell developed a specific assay to test your prospective neuraminidase inhibitor (nutraceutical, botanical, compound e.g.), enabling your company to thrive in this growing market.
Figure 1. Mechanism of action of neuraminidase inhibitors. Panel A: The role of neuraminidase
in the continued replication of virions in influenza infection. (Panel B): Replication is blocked by
neuraminidase inhibitors preventing release of virions from the surface of infected cells.
Moscona, A. (2005). Neuraminidase Inhibitors for Influenza. N Engl J Med 353: 1363-1373
 von Itzstein M (December 2007). Nature Reviews. Drug Discovery 6 (12): 967–74. doi:10.1038/nrd2400. PMID 18049471.  Palese P, Tobita K, Ueda M, Compans RW (October 1974). Virology 61 (2): 397–410. doi:10.1016/0042-6822(74)90276-1. PMID 4472498.  Liu C, Eichelberger MC, Compans RW, Air GM (February 1995). Journal of Virology 69 (2): 1099–106. PMID 7815489. PMC: 188682. Effects of neuraminidase inhibitors DANA and
Zanamavir (Relenza®) on Neuraminidase activity
from Influenza A virus and bacterial sources
NA Clostridium perfringens
NA Vibrio cholera
NA Influenza A Virus
Figure 2. Effects of the neuraminidase inhibitors DANA (N-Acetyl-2,3-dehydro-2-
deoxyneuraminic acid) and Zanamavir (Relenza) on neuraminidase activity from
Influenza A virus or the bacterial sources Clostridium perfringens and Vibrio
cholerae. Whereas DANA inhibits both neuraminidase from bacterial and viral
sources, zanamavir is mainly targeting viral neuraminidase activity. Data give proof
of the assay validity. Oseltamivir (Tamiflu) shows similar effects to Zanamavir
(Relenza) (not shown).
Inhibitory potential of botanicals/
nutraceuticals on Influenza A virus
Figure 3. Investigation of botanical extracts 1-7 concerning their capability to
inhibit neuraminidase activity from Influenza A virus. Except of extract 4, all
extracts inhibited neuraminidase activity. Extracts 1, 2, and 5 caused the strongest inihibition and might therefore be useful to protecting against flu infections.
VivaCell Biotechnology GmbH
Bernd L. Fiebich, PhD
Ferdinand-Porsche Str. 5
Recommended procedure The caloric test General forward This document presents a Recommended Procedure by the British Society of Audiology (BSA). A Recommended Procedure provides a reference standard for the conduct of an audiological intervention that represents, to the best knowledge of the BSA, the evidence-base and consensus on good practice given the stated methodology and scope