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Microsoft word - publications 2004.doc

PUBLICATIONS 2004

DEPARTMENT OF PHARMACOLOGY

Ahmad, S., Fowler, L.J., Whitton, P.S., 2004. Effect of acute and chronic lamotrigine on
basal and stimulated extracellular 5-hydroxytryptamine and dopamine in the hippocampus
of the freely moving rat. British Journal of Pharmacology 142, 136-142.
Gaitatzis, A., Kartsounis, L.D., Gacinovic, S., Costa, D.C., Harvey, K., Harvey, R.J., de
Silva, R.N., 2004. Frontal lobe dysfunction in sporadic hyperekplexia: case study and
literature review. Journal of Neurology 251, 91-98.
Harvey, K., Duguid I.C., Alldred, M.J., Beatty, S.E., Ward, H., Keep N.H., Lingenfelter,
S.E., Pearce, B.R., Lundgren, J., Owen, M.J., Smart, T.G., Lüscher, B., Rees, M.I.,
Harvey, R.J., 2004. The GDP-GTP exchange factor collybistin: an essential determinant of
neuronal gephyrin clustering. Journal of Neuroscience 24, 5816-5826.
Harvey, R.J., Depner, U.B., Wässle, H., Ahmadi, S., Heindl, C., Reinold, H., Smart, T.G.,
Harvey, K., Schütz, B., Abo-Salem, O.M., Zimmer, A., Poisbeau, P., Welzl, H., Wolfer,
D.P., Betz, H., Zeilhofer, H.U., Müller, U., 2004. GlyR α3: an essential target for spinal
PGE2 -mediated inflammatory pain sensitization. Science 304, 884-887.

Haverkamp, S., Müller, U., Zeilhofer, H.U., Harvey, R.J., Wässle, H., 2004. Diversity of
glycine receptors in the mouse retina: location of the α2 subunit. Journal of Comparative
Neurology
477, 399-411.
Miller, P.S., Harvey, R.J., Smart, T.G., 2004. Differential antagonist sensitivity of glycine
receptor α2 subunit splice variants. British Journal of Pharmacology 143, 19-26.

Moffatt, J.D., Lever, R., Page, C.P., 2004. Effects of inhaled thrombin receptor agonists in
mice. British Journal of Pharmacology 143, 269-275.

Russo, E., Constanti, A., 2004. Topiramate hyperpolarizes and modulates the slow
poststimulus AHP of rat olfactory cortical neurones in vitro. British Journal of
Pharmacology
141, 285-301.

Russo, E., Constanti, A., Ferreri, G., Citraro, R., De Sarro, G., 2004. Nifedipine affects the
anticonvulsant activity of topiramate in various animal models of epilepsy.
Neuropharmacology 46, 865-878. Segieth, J., Fowler, L. Whitton, P.S., Pearce, B., 2004. Arginine release from rat cerebellar astrocytes: autocrine roles for glutamate and nitric oxide? Neuroscience Letters 372, 262-265. Valente, E.M., Abou-Sleiman, P.M., Caputo, V., Muqit, M.M.K., Harvey, K., Gispert, S., Ali, Z., Del Turco, D., Bentivoglio, A.R., Healy, D.G., Albanese, A., Nussbaum, R., Gonzalez-Maldonaldo, R., Deller, T., Salvi, S., Cortelli, P., Gilks, W.P., Latchman, D.S., Harvey, R.J., Dallapiccola, B., Auberger, G., Wood, N.W., 2004. Hereditary early-onset Parkinson’s disease caused by mutations in PINK1. Science 304, 1158-1160. Watts, J., Segieth, J., Pearce, B., Whitton, P.S., 2004. Regulatory role of nitric oxide over
extracellular taurine in the hippocampus of freely moving rats. Neuroscience Letters 357,
179-182.

Whalley, B., J., Wilkinson, J.D., Williamson, E.M., Constanti, A., 2004. A novel component
of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in
vitro. Neuroscience Letters 365, 58-63.
CENTRE FOR TOXICOLOGY

Arrhenius, A., Gronvall, F., Scholze, M., Backhaus, T., Blanck, H., 2004. Predictability of
the mixture toxicity of 12 similarly acting congeneric inhibitors of photosystem II in marine
periphyton and epipsammon communities. Aquatic Toxicology 68, 351-367.
Cristofori, P., Crivellente, F., Campagnola, M., Pasini, A.F., Garbin, U., Rigoni, A., Tosetti,
M., Turton, J., Faustinelli, I., Cominacini, L., 2004. Reduced progression of atherosclerosis
in apolipoprotein E-deficient mice treated with lacidipine is associated with a decreased
susceptibility of low-density lipoprotein to oxidation. International Journal of Experimental
Pathology
85, 105-114.
Cristofori, P.G., Crivellente, F., Faustinelli, I., Lanzoni, A.R., Lazzarini, C., Vecchiato, E.,
Andreoli, M., Turton, J.A., Zancanaro, C., Crespi, F.M., 2004. Involvement of the nitric
oxide system in the anti-atherosclerotic potential of lacipidine in the apoE-deficient mouse:
a morphological, functional, and electrochemical study. Toxicologic Pathology 32, 493-
499.
Fischer, J.S., 2004. Are all EDC effects mediated via steroid hormone receptors?
Toxicology 205, 33-41.

Fisher, J.S., 2004. Environmental anti-androgens and male reproductive health: focus on
phthalates and testicular dysgenesis syndrome. Reproduction 127, 305-315.
Molyneux, G., Rizzo, S., Gibson, F.M., Sulsh, S., Andrews, C.M., Pilling, A., Nakshbandi,
T., Gordon-Smith, E.C., Turton, J.A., 2004. Haemoxicity of chlorambucil in the Wister
Hanovar rat with particular reference to bone marrow culture, marrow cell apoptosis and
levels of FLT3 ligand. Comparative Clinical Pathology 13, 70-81.
Peck, M., Gibson, R.W., Kortenkamp, A., Hill, E.M., 2004. Sediments are major sinks of
steroidal estrogens in two United Kingdom rivers. Environmental Toxicology and
Chemistry
23, 945-952.
Pilling, A., Jones, S., Turton, J., 2004. Expression of somatostatin mRNA and peptides in
C-cell tumours of the thyroid gland in Han Wistar rats. International Journal of
Experimental Pathology
85, 13-23.
Rajapakse, N., Silva, E., Scholze, M., Kortenkamp, A., 2004. Deviation from additivity with
estrogenic mixtures containing 4-nonylphenol and 4-tert-octylphenol detected in the E-
screen assay. Environmental Science and Technology 38, 6343-6352.
Shayer, R., Kinschesh, P., Raffray, M., Kortenkamp, A., 2004. Biomonitoring of
chromium(VI) deposited in pulmonary tissues: pilot studies of a magnetic resonance
imaging technique in a post-mortem rodent model. Biomarkers 9, 32-46.
DEPARTMENT OF PHARMACEUTICAL AND BIOLOGICAL CHEMISTRY

Griffiths, W.J., Alvelius, G., Liu, S., Sjövall, J., 2004. High-energy collision-induced
dissociation of oxosteroids derivatised to Girard hydrazones. European Journal of Mass
Spectrometry
10, 63-88.
Groc, L., Heine, M., Cognet, L., Brickley, K., Stephenson, F.A., Lounis, B., Choquet, D.,
2004. Differential activity-dependent regulation of the lateral mobilities of AMPA and
NMDA receptors. Nature Neuroscience 7, 695-696.
Hawkins, L.M., Prybylowski, K., Chang, K., Moussan, C., Stephenson, F.A., Wenthold,
R.J., 2004. Export from the endoplasmic reticulum of assembled N-methyl-D-aspartic acid
receptors is controlled by a motif in the C terminus of the NR2 subunit. Journal of
Biological Chemistry
279, 28903-28910.
Juntti-Berggren, L., Refai, E., Appelskog, I., Andersson, M., Imreh, G., Dekki, N., Uhles,
S., Yu, L., Griffiths, W.J., Zaitsev, S., Leibiger, I., Yang, S-N., Olivecrona, G., Jörnvall, H.,
Berggren, P-O., 2004. Apolipoprotein CIII promotes Ca2+-dependent β cell death in type 1
diabetes. Proceedings of the National Academy of Sciences of the United States of
America
101, 10090-10094.
Kan, P.L., Papahadjopoulos-Sternberg, B., Wong, D., Waigh, R.D., Watson, D.G., Gray,
A.I., McCarthy, D., McAllister, M., Schatzlein, A.G., Uchegbu, J.F., 2004. Highly hydrophilic
fused aggregates (microsponges) from a C12 spermine bolaamphiphile. Journal of
Physical Chemistry B
108, 8129-8135.
Lane, C.S., Nisar, S., Griffith, W.J., Fuller, B.J., Davidson, B.R., Hewes, J., Welham, K.J.,
Patterson, L.H., 2004. Identification of cytochrome P450 enzymes in human colorectal
metastases and the surrounding liver: a proteomic approach. European Journal of Cancer
40, 2127-2134.
Lengqvist J., Mata de Urquiza A., Bergman, A-C., Willson, T.M., Sjövall, J., Perlmann, T.,
Griffiths. W.J., 2004. Polyunsaturated fatty acids including docosahexaenoic and
arachidonic acid bind to the retinoid X receptor α ligand-binding domain. Molecular &
Cellular Proteomics
3, 692-703.
Lenqvist, J., Svensson, R., Evergren, E., Morgenstern, R., Griffiths, W.J., 2004.
Observation of an intact noncovalent homotrimer of detergent-solubilized rat microsomal
glutathione transferase-1 by electrospray mass spectrometry. Journal of Biological
Chemistry
279, 13311-13316.
Liere, P., Pianos, A., Eychenne, B., Cambourg, A., Liu, S., Griffiths, W., Schumacher, M.,
Sjövall, J., Baulieu, E-E., 2004. Novel lipoidal derivatives of pregnenolone and
dehydroepiandrosterone and absence of their sulphated counterparts in rodent brain.
Journal of Lipid Research 45, 2287-2302.
Nisar, S., Lane, C.S., Wilderspin, A.F., Welham, K.J., Griffiths, W.J., Patterson, L. H, 2004.
A proteomic approach to the identification of cytochrome P450 isoforms in male and
female rat liver by nanoscale liquid chromatography-electrospray ionization-tandem mass
spectrometry. Drug Metabolism and Disposition 32, 382-386.
Norberg, Ǻ., Griffiths, W.J., Hjelmqvist, L., Jornvall, H., Rökaeus, Ǻ., 2004. Identification of variant forms of the neuroendocrine peptide galanin. Rapid Communications in Mass Spectrometry 18, 1583-1591. Papadakis, M., Hawkins, L.M., Stephenson, F.A., 2004. Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-asparate NR1/NR2 receptors. Journal of Biological Chemistry 279, 14703-14712. Peran, M., Hooper, H., Rayner, S.L., Stephenson, F.A., Salas, R., 2004. GABAA receptor α1 and α6 subunits mediate cell surface anchoring in cultured cells. Neuroscience Letters
364, 67-70.
Pors, K., Paniwnyk, Z., Ruparelia, K.C., Teesdale-Spittle, P.H., Hartley, J.A., Kelland, L.R.,
Patterson, L.H., 2004. Synthesis and biological evaluation of novel
chloroethylaminoanthraquiones with potent cytotoxic activity against cisplatin-resistant
tumor cells. Journal of Medicinal Chemistry 47, 1856-1859.
Rai, D.K., Green, B.N., Landin, B., Alvelius, G., Griffiths, W.J., 2004. Accurate mass
measurement and tandem mass spectrometry of intact globin chains identify the low
proportion variant haemoglobin Lepore-Boston-Washington from the blood of a
heterozygote. Journal of Mass Spectrometry 39, 289-294.
Searcey, M., Patterson, L.H., 2004. Resistance in cancer: a target for drug discovery.
Current Medicinal Chemistry – Anti-Cancer Agents 4, 457-460.
Tjernberg, A., Carnö, S., Oliv, F., Benkestock, K., Edlund, P-O., Griffiths, W.J., Hallén, D.,
2004. Determination of dissociation constants for protein-ligand complexes by electrospray
ionization mass spectrometry. Analytical Chemistry 76, 4235-4331.
Wang, Y., Johansson, J., Agerbath, B., Jörnvall, H., Griffiths, W.J., 2004. The antimicrobial
peptide LL-37 binds to the human plasma protein apolipoprotein A-I. Rapid
Communications in Mass Spectrometry
18, 588-589. [Letter]
Zloh, M., Gibbons, S., 2004. Molecular similarity of MDR inhibitors. International Journal of
Molecular Sciences
5, 37-47.
Zloh, M., Kaatz, G.W., Gibbons, S., 2004. Inhibitors of multidrug resistance (MDR) have
affinity for MDR substrates. Bioorganic and Medicinal Chemistry Letters 14, 881-885.
Other outputs

Malkinson, J.P., 2004. Pharmacists are scientists and clinicians. Pharmaceutical Journal
273, 113. [Letter]
Not previously reported

Malkinson, J.,P., Falconer, R.A., 2003. Solid-phase synthesis of C-terminal thio-linked
glycopeptides. In: Chorev, M., Sawyer, T.K. (Eds.), Peptide Revolution: Genomics,
Proteomics & Therapeutics: Proceedings of the 18th American Peptide Symposium. Boston
19-23 July 2003. American Peptide Society, pp. 73-74.
Malkinson, J.P., Searcey, M., 2003. Solid-Phase Synthesis of Des-N-Tetramethyl Triostin
A (TANDEM). In: Chorev, M., Sawyer, T.K. (Eds.), Peptide Revolution: Genomics,
Proteomics & Therapeutics: Proceedings of the 18th American Peptide Symposium. Boston
19-23 July 2003. American Peptide Society, pp. 53-54.
CENTRE FOR PHARMACOGNOSY AND PHYTOTHERAPY

Appendino, G., Mercalli, E., Fuzzati, N., Arnoldi, L., Stavri, M., Gibbons, S., Ballero, M.,
Maxia, A., 2004. Anti-mycobacterial Coumarins from Sardinian Giant Fennel (Ferula
communis
). Journal of Natural Products 67, 2108-2110.
Appendino, G., Bianchi, F., Bader, A., Camagnuolo, C., Fattorusso, E., Tagliatela-Scafati,
O., Blanco-Molina, M., Macho, A., Fiebich, B.L., Bremner, P., Heinrich, M., Ballero, M.,
Muñoz, E., 2004. Coumarins from Opopanax chironium. New dihydrofuranocoumarins and
differential induction of apoptosis by imperatorin and heraclenin. Journal of Natural
Products
67, 532-536.
Barnes, J., Anderson, L.A., Phillipson, J.D., 2004. Herbal Medicines 2004: single user
version
[CD-ROM]. Pharmaceutical Press, London, 2004.
Beha, E., Jung, A., Wiesner, J., Rimpler, H., Lanzer, M., Heinrich, M., 2004. Antimalarial
activity of extracts of abuliton grandiflorum G.Don – a traditional Tanzanian medicinal
plant. Phytotherapy Research 18, 236-240.

Bremner, P., Tang, S., Birkmayer, H., Fiebich, B.L., Muñoz, E., Marquez, N., Rivera, D.,
Heinrich, M., 2004. Phenylpropanoid NF-κB inhibitors from Bupleurum fructicosum. Planta
Medica
70, 914-918.

Camacho, M.D., Phillipson, J.D., Croft, S.L., Yardley, V., Solis, P.N., 2004. In vitro
antiprotozoal and cytoxic activities of some alkaloids, quinones, flavonoids, and
coumarins. Planta Medica 70, 70-72.
Delazar, A., Byres, M., Gibbons, S., Kumarasamy, Y., Nahar, L., Shoeb, M., Sarker, S.D.,
2004. Iridoid glycosides from Eremostachys glabra. Journal of Natural Products 67, 1584-
1587.
Delazar, A., Gibbons, S., Kumaraswamy, Y., Nahar, L., Shoeb, M., Sarker, S.D., 2005.
Antioxidant phenylethanoid glycosides from Eremostachys glabra (Lamiaceae).
Biochemical Systematics and Ecology 33, 87-90.
Elsabagh, S., Hartley, D., Randall, D., Seth, P., File, S.E., 2004. Mood changes after
cognitive testing in late middle age: impacts of sex and habitual alcohol consumption.
Pharmacology Biochemistry and Behaviour 78, 621-628.
Gibbons, S., 2004. Anti-staphylococcal plant natural products. Natural Product Reports 21,
263-277.
Gibbons, S., Moser, E., Kaatz, G.W., 2004. Catechins gallates inhibit multidrug resistance
(MDR) in Staphylococcus aureus. Planta Medica 70, 1240-1242.
Hartley, D.E., Elsabagh, S., File, S.E., 2004. Binge drinking and sex: effects on mood and
cognitive function in healthy young volunteers. Pharmacology Biochemistry and Behaviour
78, 611-619.

Heinrich, M., (2004) Mensch und Arzneipflanzen: Medizin aus dem Regenwald? In:
Graichen, G. (Ed.), Heilwissen, Econ Verlag, Berlin.
Heinrich, M., (2004) Mensch und Arzneipflanzen: Medizinische Ethnobotanik in Mexiko. In:
Graichen, G. (Ed.), Heilwissen, Econ Verlag, Berlin.

Heinrich, M., 2004. Searching for new anti-inflammatory and anti-infective products from
plants. Pharmaceutical Journal 272, 358-359.

Heinrich, M., 2004. Snowdrops: the heralds of spring and a modern drug for Alzheimers
disease. Pharmaceutical Journal 273, 905-906.

Heinrich, M., Teoh, H.L., 2004. Galanthamine from snowdrop – the development of a
modern drug against Alzheimer’s disease from local Caucasian knowledge. Journal of
Ethnopharmacology
92, 147-162.
Lechner, D., Stavri, M., Oluwatuyi, M., Pereda-Miranda, R., Gibbons, S., 2004. The anti-
staphylococcal activity of Angelica dahurica (Bai Zhui). Phytochemistry 65, 331-335.
Macho, A., Blanco-Molina, M., Spagliardi, P., Appendino, G., Bremner, P., Heinrich, M.,
Fiebich, B.L., Muñoz, E., 2004. Calcium ionophoretic and apoptic effects of ferutinin in the
human Jurkat T-cell line. Biochemical Pharmacology 68, 875-883.

Marquez, N., Sancho, R., Ballero, M., Bremner, P., Appendino, G., Fiebich, B.L., Heinrich,
M., Munoz, E., 2004. Imperatonin inhibits T-cell proliferation by targeting the transcription
factor NFAT. Planta Medica 70, 1016-1021.

Oluwatuti, M., Kaatz, G., Gibbons, S., 2004. Antibacterial and resistance modifying activity
of rosmarinus officinalis. Phytochemistry 65, 3249-3254.
Randall. D.C., Elsabagh, S.M., Hartley, D.E., File, S.E., 2004. Does drinking have effects
on mood and cognition in male and female students? Pharmacology Biochemistry and
Behaviour
78, 629-638.
Schneider, I., Gibbons, S., Bucar, F., 2004. Inhibitory activity on 12(s)-HETE production in
human platelets. Planta Medica 70, 471-474.
Simonsen, H.T., Adsersen, A., Bremner, P., Heinrich, M., Smitt, U.W., Jaroszewski, J.W.,
2004. Antifungal constituents of Melicope borbonica. Phytotherapy Research 18, 542-545.
Stavri, M., Mathew, K.T., Gibson, T., Williamson, R.T., Gibbons, S., 2004. New
constituents of Artemisia monosperma. Journal of Natural Products 67, 892-894.
Stavri, M., Schneider, R., O’Donnell, G., Lechner, D., Bucar, F., Gibbons, S., 2004. The
antimycobacterial components of Hops (Humulus lupulus) and their dereplication.
Phytotherapy Research 18, 774-776.
Whalley, B., J., Wilkinson, J.D., Williamson, E.M., Constanti, A., 2004. A novel component
of cannabis extract potentiates excitatory synaptic transmission in rat olfactory cortex in
vitro. Neuroscience Letters 365, 58-63.
Zloh, M., Gibbons, S., 2004. Molecular similarity of MDR inhibitors. International Journal of
Molecular Sciences
5, 48-55.
Zloh, M., Kaatz, G.W., Gibbons, S., 2004. Inhibitors of multidrug resistance (MDR) have
affinity for MDR substrates. Bioorganic and Medicinal Chemistry Letters 14, 881-885.
Other outputs

Heinrich, M. (2004) Interview in ‘Fliege-die Talkshow.’ ARD, Germany (Bayrischer
Rundfunk), 31 March 2004. [Interview]
Heinrich, M., 2004. The extra year is for integrating science and practice. Pharmaceutical
Journal
273, 51. [Letter]
Heinrich, M. (Scientific advisor and co-operation partner), 2004. Heilwissen der Maya
[Healing Knowledge of the Maya], documentary in the series Heilwissen [Healing
Knowledge]. Directed by Andreas Orth. ZDF, Mainz, 21 March 2004. [TV Programme]
Houghton, P., Barnes, J., 2004. Pharmacognosy in the curriculum: a critical need that still
needs to be met. Pharmaceutical Journal 273, 325. [Forum Report]
Kufer, J., 2004. Plant systematics: a phylogenetic approach, second edition. Journal of
Ethnopharmacology
90, 180-1. [Book Review]
Tovey, P., Barnes, J., 2004. Editorial. Complementary Therapies in Medicine 12, 1.

CENTRE FOR PHARMACEUTICAL ANALYSIS

Fertig, C.C., Podczeck, F., Jee, R.D., Smith, M.R., 2004. Feasibility study for the rapid
determination of the amylase content in starch by near-infrared spectroscopy. European
Journal of Pharmaceutical Sciences
21, 155-159.
Moffat, A.C., 2004. Validation of NIR methods for pharmaceutical analyses. In: Davies,
A.M.C., Carrido-Varo, A. (Eds.), Near Infrared Spectroscopy: Proceedings of the 11th
International Conference. Cordoba 6-11 April 2003. NIR Publications, Chichester, pp. 841-
845.
Smith, M.R., Jee, R.D., Moffat, A.C., Rees, D.R., Broad, N.W., 2004. A procedure for
calibration transfer between near-infrared instruments – a worked example using a
transmittance single tablet assay for piroxicam in intact tablets. Analyst 129, 806-816.
Yoon, W.L., Jee, R.D., Charvill, A., Lee, G., Moffat, A.C., 2004. Application of near-infrared
spectroscopy to the determination of the sites of manufacture of proprietary products.
Journal of Pharmaceutical and Biomedical Analysis 34, 933-944.
CANCER RESEARCH UK BIOMOLECULAR STRUCTURE GROUP

Caceres, C., Wright, G., Gouyette, C., Parkinson, G., Subirana, J.A., 2004. A thymine
tetrad in d(TGGGGT) quadruplexes stabilized with T1+/Na+ ions. Nucleic Acids Research
32, 1097-1102.
Guyen, B., Schultes, C.M., Hazel, P., Mann, J., Neidle, S., 2004. Synthesis and evaluation
of analogues of 10H-indolo[3,2-b]-quinoline as G-quadruplex stabilising ligands and
potential inhibitors of the enzyme telomerase. Organic and Biomolecular Chemistry 2, 981-
988.
Harrison, R.J., Reszka, A.P., Haider, S.M., Romagnoli, B., Morrell, J., Read, M.A., Gowan,
S.M., Incles, C.M., Kelland, L.R., Neidle, S., 2004. Evaluation of by disubstituted acridone
derivatives as telomerase inhibitors: the importance of G-quadruplex binding. Bioorganic
and Medicinal Chemistry Letters
14, 5845-5849.
Hazel, P., Huppert, J., Balasubramanian, S., Neidle, S., 2004. Loop-length-dependent
folding of G-quadruplexes. Journal of the American Chemical Society 126, 16405-16415.
Incles, C.M., Schultes, C.M., Kempski, H., Koehler, H., Kelland, L.R., Neidle, S., 2004. A
G-quadruplex telomere targeting agents produces p16-associated senescence and
chromosomal fusions in human prostate cancer cells. Molecular Cancer Therapeutics 3,
1201-1206.
Ladame, S., Schouten, J.A., Stuart, J., Roldan, J., Neidle, S., Balasubramanian, S., 2004.
Tetrapeptides induce selective recognition for G-quadruplexes when conjugated to a DNA-
binding platform. Organic and Biomolecular Chemistry 2, 2925-2931.
Mallena, S., Lee, M., Bailly, C., Neidle, S., Kumar, A., Boykin, D.W., Wilson, W.D., 2004. A
thiophene based diamidine forms a “super” AT binding minor groove agent. Journal of the
American Chemical Society
126, 13659-13669.

Nguyen, B., Hamelberg, D., Bailly, C., Colson, P., Stanek, J., Brun, R., Neidle, S., Wilson,
W.D., 2004. Characterization of a novel DNA minor-groove complex. Biophysical Journal
86, 1028-1041.
Peña Ruiz, T., Fernández-Gómez, M., López González, J.J., Kozial, A.E., Granadino
Roldán, J.M., 2004. Weak C-H···π hydrogen bonds in crystal 1-indanone. An structural and
spectroscopic analysis. Journal of Molecular Structure 707, 33-46.
Schultes, C.M., Guyen, B., Cuesta, J., Neidle, S., 2004. Synthesis, biophysical and
biological evaluation of 3,6-bis-amidoacridines with extended 9-anilino substituents as
potent G-quadruplex-binding telomerase inhibitors. Bioorganic & Medicinal Chemistry
Letters
14, 4347-4351.
Other outputs

Neidle, S., de Souza, J., 2004. Stephen Neidle on cancer therapy and G-Quadruplex
inhibitors. Drug Discovery Today 9, 778-781. [Interview]
CANCER RESEARCH UK GENE TARGETED DRUG DESIGN RESEARCH GROUP

Alley, M.C., Hollingshead, M.G., Pacula-Cox, C.M., Waud, W.R., Hartley, J.A., Howard,
P.W., Gregson, S.J., Thurston, D.E., Sausville, E.A., 2004. SJG-136 (NSC 694501), A
novel rationally designed DNA minor groove interstrand cross-linking agent with potent
and broad spectrum antitumor activity. Part 2: efficacy evaluations. Cancer Research 64,
6700-6706.
Chen, Z., Gregson, S.J., Howard, P.W., Thurston, D.E., 2004. A novel approach to the
synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c][1,4] benzodiazepines (PBDs) with
conjugated acrylyl C2-substituents. Biorganic and Medicinal Chemistry Letters 14, 1547-
1549.
Gregson, S.J., Howard, P.W., Gullick, D.R., Hamaguchi, A., Corcoran, K.E., Brooks, N.A.,
Hartley, J.A., Jenkins, T.C., Patel, S., Guille, M.J., Thurston, D.E., 2004. Linker length
modulates DNA cross-linking reactivity and cytotoxic potency of C/8/C8’ ether linked C2-
exo-unsaturated pyrrolo [2,1-c][1,4]benzodiazepine (PBD) dimers. Journal of Medicinal
Chemistry
47, 1161-1174.
Hartley, J.A., Spanswick, V.J., Brooks, N., Clingen, P.H., McHugh, P.J., Hochhauser, D.,
Pedley, R.B., Kelland, L.R., Alley, M.C., Schultz, R., Hollingshead, M.G., Schweikart, K.M.,
Tomaszewski, J.E., Sausville, E.A., Gregson, S.J., Howard, P.W., Thurston, D. 2004. SJG-
136 (NSC 694501), A novel rationally designed DNA minor groove interstrand cross-
linking agent with potent and broad spectrum antitumor activity. Part 1: cellular
pharmacology, in vitro and initial in vivo antitumor activity. Cancer Research 64, 6693-
6699.
Masterson, L.A., Croker, S.J., Jenkins, T.C., Howard, P.W., Thurston, D.E., 2004.
Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic
amine conjugates. Bioorganic and Medicinal Chemistry Letters 14, 901-904.
Pepper, C.J., Hambly, R.M., Fegan, C.D., Delavault, P., Thurston, D.E., 2004. The novel
sequence-specific DNA cross-linking agent SJG-136 (NSC 694501) has potent and
selective in vitro cytotoxicity in human b-cell chronic lymphocytic leukaemia cells with
evidence of a p53-independent mechanism of cell kill. Cancer Research 64, 6750-6755.
Tiberghien, A.C., Hagan, D., Howard, P.W., Thurston, D.E., 2004. Application of the Stille
coupling reaction to the synthesis of C2-substitued endo-exo unsaturated pyrrolo[2,1-
c][1,4] benzodiazepines (PBDs). Bioorganic and Medicinal Chemistry Letters 14, 5041-
5044.
Wilkinson, G.P., Taylor, J.P., Shnyder, S., Cooper, P., Howard, P.W., Thurston, D.E.,
Jenkins, T.C., Loadman, P.M., 2004. Preliminary pharmacokinetic and bioanalytical
studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimmer
DNA-cross-linking agent. Investigational New Drugs 22, 231-240.
DEPARTMENT OF PHARMACEUTICS

Al-Hadithi, D., Buckton, G., Brocchini, S., 2004. Quantification of amorphous content in
mixed systems: amorphous trehalose with lactose. Thermochimica Acta 417, 193-199.
Backhouse, L., Dias, M., Gorce, J.P., Hadgraft, J., McDonald, P.J., Wiechers, J.W., 2004.
GARField magnetic resonance profiling of the ingress of model skin-care product
ingredients into human skin in vitro. Journal of Pharmaceutical Sciences 93, 2274-2283.
Barriocanal L., Taylor, K.M.G., Buckton, G., 2004. A study of liposome formation using
solution (isoperibol) calorimetry. International Journal of Pharmaceutics 287, 113-121.
Bashaiwoldu, A.B., Podczeck, F., Newton, J.M., 2004. A study on the effect of drying
techniques on the mechanical properties of pellets and compacted pellets. European
Journal of Pharmaceutical Sciences
21, 119-129.
Bashaiwoldu, A.B., Podczeck, F., Newton, J.M., 2004. Application of Dynamic Mechanical Analysis (DMA) to the determination of the mechanical properties of coated pellets. International Journal of Pharmaceutics 274, 53-63. Bashaiwoldu, A.B., Podczeck, F., Newton, J.M., 2004. Application of dynamic mechanical analysis (DMA) to determine the mechanical properties of pellets. International Journal of Pharmaceutics 269, 329-342. Bashaiwoldu A.B., Podczeck, F., Newton, J.M., 2004. The application of non-contact laser profilometry to the determination of permanent structural changes induced by compaction of pellets. I. Pellets of different composition. European Journal of Pharmaceutical Sciences 21, 143-154. Bashaiwoldu A.B., Podczeck, F., Newton, J.M., 2004. The application of non-contact laser profilometry to the determination of permanent structural changes induced by compaction of pellets. II. Pellets dried by different techniques. European Journal of Pharmaceutical Sciences 22, 55-61. Basit, A.W., Podczeck, F., Newton, J.M., Waddington, W.A., Ell, P.J., Lacey, L.F., 2004. The use of formulation technology to assess regional gastrointestinal drug absorption in humans. European Journal of Pharmaceutical Science 21, 179-189. Beezer, A.E., 2004. Microcalorimetry for the pharmaceutical industry. In: Letcher, T.M. (Ed.), Chemical Thermodynamics for Industry. The Royal Society of Chemistry, Cambridge, pp. 104-109. Buckton, G., Ambarkhane, A., Pincott, K., 2004. The use of inverse phase gas chromatography to study the glass transition temperature of a powder surface. Pharmaceutical Research 21, 1554-1557. Carter, R.E., Newton, J.M., Caminho, A.M., Mascia, S., 2004. A Novel System for the Controlled Release of Drugs. Pharmaceutical Technology Europe, 23-29. Chatchawalsaisin, J., Podczeck, F., Newton, J.M., 2004. The influence of chitosan and sodium alginate and formulation variables on the formation and drug release from pellets prepared by extrusion/spheronisation. International Journal of Pharmaceutics 275, 41-60. Dias, M., Hadgraft, J., Raghavan, S.L., Tetteh, J., 2004. The effect of solvent on permeant diffusion through membranes studied using ATR-FTIR and Chemometric Data Analysis. Journal of Pharmaceutical Sciences 93, 186-196. Dilworth, S.E., Buckton, G., Gaisford, S., Ramos, R., 2004. Approaches to determine the enthalpy of crystallisation, and amorphous content, of lactose from isothermal calorimetric data. International Journal of Pharmaceutics 284, 83-94. Elhissi, A.M.A., Taylor, K.M.G., 2004. An inhalable liposome formulation generated from proliposomes within a jet nebulizer. In: Respiratory Drug Delivery IX: Biological, Pharmaceutical, Clinical Regulatory Issues Relating to Optimized Drug Delivery by Aerosol. Virginia Commonwealth University, Richmond, pp.781-784. Fourie, L., Breytenbach, J.C., du Plessis, J., Goosen, C., Swart, H., Hadgraft, J., 2004.
Percutaneous delivery of carbamazepine and selected N-alkyl and N-hydroxyalkyl
analogues. International Journal of Pharmaceutics 279, 59-66.
Gaisford, S., Royall, P.G., Greig, D.G.T., 2004. Solution calorimetry as a tool to study the
neutralising capacity of magnesium trisilicate mixture BP and its components.
Thermochimica Acta 417, 217-221.
Gathago, E.W., Waugh, A.C.W., Perić-Concha, N., Redpath, M.B., Long, P.F., 2004.
Rapid detection of ‘rare’ actinomycetes in environmental samples. Biotechnology Letters
26, 897-900.
Gohil, U.C., Podczeck, F., Turnbull, N., 2004. Investigations into the use of pregelatinised
starch to develop powder-filled hard capsules. International Journal of Pharmaceutics 285,
51-63.
Hadgraft, J., 2004. Skin Deep. European Journal of Pharmaceutics and Biopharmaceutics
58, 291-299.
Hadgraft, J., Guy, R., 2004. Biotechnological aspects of transport across human skin.
Biotechnology and Genetic Engineering Reviews 21, 183-193.

Hitch, G., Pratten, J., Taylor, P.W., 2004. Isolation of bacteriophages from the oral cavity.
Letters in Applied Microbiology 39, 215-219.
Ibekwe, V.C., Kendall, R.A., Basit, A.W., 2004. Drug delivery to the colon. The Drug
Delivery Companies Report
(Spring/Summer), PharmaVentures Ltd, Oxford, UK, 27-30.
Jibry, N., Heenan, R., Murdan, S., 2004. Amphiphilogels for drug delivery: formulation and
characterization. Pharmaceutical Research 21, 1852-1861.
Jibry N., Murdan, S., 2004. In vivo investigation, in mice and in man, into the irritation
potential of novel amphiphilogels being studied as transdermal drug carriers. European
Journal of Pharmaceutics and Biopharmaceutics
58, 107-119.
Leveque, N., Makki, S., Hadgraft, J., Humbert, P., 2004. Comparison of Franz cells and
microdialysis for assessing salicylic acid penetration through human skin. International
Journal of Pharmaceutics
269, 323-328.

McGregor, C., Saunders, M.H., Buckton, G., Saklatvala, R.D., 2004. The use of high-
speed differential scanning calorimetry (hyper-DSCTM) to study the thermal properties of
carbamazepine polymorphs. Thermochimica Acta 417, 231-237.

Murdan, S., 2004. Nail varnish as a drug delivery vehicle. The Drug Delivery Companies
Report
(Spring/Summer), PharmaVentures Ltd, Oxford, UK, 40-42.
Mushtaq, N., Redpath, M.B., Luzio, J.P., Taylor, P.W., 2004. Prevention and cure of
systematic Escherichia coli K1 infection by modification of the bacterial phenotype.
Antimicrobial Agents and Chemotherapy 48, 1503-1508.
Newell, H.E., Buckton, G., 2004. Inverse gas chromatography: investigating whether the
technique preferentially probes high energy sites for mixtures of crystalline and amorphous
lactose. Pharmaceutical Research 21, 1440-1444.

Newton, J.M., 2004. Drug release from capsules. In: Podczeck, F., Jones, B.E. (Eds.),
Pharmaceutical Capsules, 2nd ed., Pharmaceutical Press, London. pp. 213-237.
Newton, J.M., Boutel, S., Chatchawalsaisin, Podczeck, F., 2004. The Preparation of
Spherical Granules by Extrusion/Spheronization without Microcrystalline Cellulose.
Pharmaceutical Technology Europe, 21-27.
Ohta, M., Buckton, G., 2004. Determination of the changes in surface energetics of
cefditoren pivoxil as a consequence of processing induced disorder and equilibration to
different relative humidities. International Journal of Pharmaceutics 269, 81-88.
Ohta, M., Buckton, G., 2004. The use of inverse gas chromatography to assess the acid
base contributions to surface energies of cefditoren pivoxil and methacrylate copolymers
and possible links to instability. International Journal of Pharmaceutics 272, 121-128.
Parmar, M.K., Beezer, A.E., Willson, R.J., 2004. An isothermal microcalorimetric study of
the imidazole catalysed hydrolosis of triacetin and the observed rate constant dependence
of triacetin concentration. Thermochimica Acta 424, 219-222.
Pinkrah, V.T., Beezer, A.E., Chowdry, B.Z., Gracia, L.H., Mitchell, J.C., Snowden, M.J.,
2004. Thermodynamic considerations of microgel swelling behaviour. Langmuir 20, 8531-
8536.

Samra, R.M., Buckton, G., 2004. The crystallisation of a model hydrophobic drug
(terfenadine) following exposure to humidity and organic vapours. International Journal of
Pharmaceutics
284, 53-60.
Saunders, M., Podluii, K., Shergill, S., Buckton, G., Royall, P., 2004. The potential of high
speed DSC (Hyper-DSC) for the detection and quantification of small amounts of
amorphous content in predominantly crystalline samples. International Journal of
Pharmaceutics
274, 35-40.
Seidel, V., Taylor, P.W., 2004. In vitro activity of extracts and constituents of Pelagonium
against rapidly growing mycobacteria. International Journal of Antimicrobial Agents 26,
613-619.
Shaunak, S., Thomas, S., Gianasi, E., Godwin, A., Jones, E., Teo, I., Mireskandari, K.,
Luthert, P., Duncan, R., Patterson, S., Khaw, P., Brocchini, S., 2004. Polyvalent dendrimer
glucosamine conjugates prevent scar tissue formation. Nature Biotechnology 22, 977-984.
Siew, L.F., Man, S-M., Newton, J.M., Basit, A.W., 2004. Amylose formulations for drug
delivery to the colon: a comparison of two fermentation models to assess colonic targeting
performance in vitro. International Journal of Pharmaceutics 273, 129-134.
Stapleton, P., Pike, R., Mullany, P., Lucas, V., Roberts, G., Rowbury, R., Wilson, M.,
Richards, H., 2004. Mercuric resistance genes in gram-positive oral bacteria. FEMS
Microbiology Letters
236, 213-220.
Stapleton, P.D., Shah, S., Anderson, J.C., Hara, Y., Hamilton-Miller, J.M., Taylor, P.W.,
2004. Modulation of β-lactam resistance in staphylococcus aureus by catechins and
gallates. International Journal of Antimicrobial Agents 23, 462-467.
Stapleton, P.D., Shah, S., Hamilton-Miller, J.M., Hara, Y., Nagaoka, Y., Kumagai, A.,
Uesato, S., Taylor, P.W., 2004. Anti-staphylococcus aureus activity and oxacillin
resistance modulating capacity of 3-O-acyl-catechins. International Journal of Antimicrobial
Agents
24, 374-380.
Taylor, K.M.G., Bates, I.P., Harding, G., 2004. The implications of increasing students for
pharmacy education. Pharmacy Education 4, 33-39.
Taylor, K.M.G., Harding, G., Bissenden, B., Shephers, O., Shooter, B., 2004. “It made me
feel like a pharmacist, not just a science student”: pharmacy undergraduate’s attitudes
towards extemporaneous dispensing practical classes. Pharmacy Education 4, 137-142.
Taylor, K.M.G., Nettleton, S.J., Harding, G., 2004. Sociology for Pharmacists: an
Introduction. (Japanese Edition) Kyoritsu Shuppan Co., Japan.
Trottet, L., Merly, C., Mirza, M., Hadgraft, J., Davis, A.F., 2004. Effect of finite doses of
propylene glycol on enhancement of in vitro percutaneous permeation of loperamide
hydrochloride. International Journal of Pharmaceutics 274, 213-219.
Tuleu, C., Newton, M., Rose, J., Euler, D., Saklatvala, R., Clarke, A., Booth, S., 2004.
Comparative bioavailability study in dogs of self-emulsifying formulation of progesterone
presented in a pellet and liquid form compared with an aqueous suspension of
progesterone. Journal of Pharmaceutical Sciences 93, 1495-1502.
Urakami, K., Beezer, A.E., 2004. A method to reduce the equilibration time prior to data
capture in ampoule-based isothermal microcalorimetric studies. Thermochimica Acta 410,
109-117.
Urakami, K., Hosoya, K., Beezer, A.E., 2004. Calorimetry and liquid chromatography:
determination of enthalpies of transfer from mobile phase to stationary phase.
Thermochimica Acta 424, 157-163.
Vicent, M.J., Tomlinson, R., Brocchini, S., Duncan, R., 2004. Polyacetal-diethylstilboestrol:
a polymeric drug designed for pH-triggered activation. Journal of Drug Targeting 12, 491-
501.
Vora, K.L., Buckton, G., Clapham, D., 2004. The use of dynamic vapour sorption and near
infra-red spectroscopy (DVS-NIR) to study the crystal transitions of theophylline and the
report of a new solid-state transition. European Journal of Pharmaceutical Sciences 22,
97-105.
Other outputs

Bistrussu, S., Beeton, A., Castaldo, G., Han, J., Wong, I., Tuleu, C., Long, P.F., Brown, K.,
Cross, N., Cope, J., Goldman, A.P., Karimova, A., O’Callaghan, M., Robertson, A., Smith,
L., 2004. Are extracorporeal membrane oxygenation circuits that are primed with
plasmalyte and stored a likely source of infection? Journal of Clinical Microbiology 42,
3906. [Letter]
Gaisford, S., Loh, W., Royall, P.G., 2004. Preface. Thermochima Acta 417,183.
Harding G., Taylor, K.M.G., 2004. Pharmacy’s strength lies in its blend of clinical, scientific
and social skills. Pharmaceutical Journal 273, 126.

Long, P.F., 2004. What pharmacists really need to know about pharmacogenomics.
Pharmaceutical Journal 273, 756 (Letter).
Patent

Newton, J.M., Carter, R., 2004. Controlled release devices with lumens. WIPO Patent WO
2004/112755 A1, 29 December.
CENTRE FOR DRUG DELIVERY RESEARCH

Alpar H.O., Somavarapu, S., Atuah, K.N., Bramwell, V.W., 2005. Biodegradable
mucoadhesive particles for nasal and pulmonary antigen and DNA delivery. Advanced
Drug Delivery Reviews
57, 411-430.
Eyles, J.E., Carpenter, Z.C., Alpar, H.O., Williamson, E.D., 2004. Immunological aspects
of polymer microsphere vaccine delivery systems. Journal of Drug Targeting 11, 509-514.
Eyles, J.E., Elvin, S.J., Westwood, A., Lebutt, C.S., Alpar, H.O., Somavarapu, S.,
Williamson, E.D., 2004. Immunisation against plague by transcutaneous and intradermal
application of subunit antigens. Vaccine 22, 4365-4373.
Florence, A.T., 2004. Issues in oral nanoparticle drug carrier uptake and targeting. Journal
of Drug Targeting
12, 65-70.
Florence, A.T., Nasseri, B., Arunothyanun, P., 2004. Does shape matter? Spherical,
polyhedral and tubular vesicles. In: Svenson, S. (Ed.), Carrier-based drug delivery: ACS
Symposium Series 879
. American Chemical Society, Washington. pp. 75-84.
Howard, K.A., Li, X.W., Somavarapu, S., Singh, J., Green, N., Atuah, K.N., Ozsoy, Y.,
Seymour, L.W., Alpar, H.O., 2004. Formulation of a microparticle carrier for oral polyplex-
based DNA vaccines. Biochimica et Biophysica Acta 1647, 149-157.
Jain, S., Hreczuk-Hirst, Laing, P., Gregoriadis, G., 2004. Polysialylation: the natural way to
improve the stability and pharmacokinetics of protein and peptide drugs. Drug Delivery
Systems and Sciences
4, 3-9.
Jaitely, V., Sakthivel, T., Magee, G., Florence, A.T., 2004. Formulation of oil in oil
emulsions: potential drug reservoirs for slow release. S.T.P. Pharma Sciences 14, 113-
117.
Kohli, A.K., Alpar, H.O., 2004. Potential use of nanoparticles for transcutaneous vaccine
delivery: effect of particle size and charge. International Journal of Pharmaceutics 275, 13-
17.
Kusoniwiriyawong, C., Atuah, K., Alpar, O.H., Merkle, H.P., Walter, E., 2004. Cationic
stearylamine-containing biodegradable microparticles for DNA delivery. Journal of
Microencapsulation
21, 25-36.
Moschos, S.A., Bramwell, V.W., Somavarapu, S., Alpar, H.O., 2004. Adjuvant synergy: the
effects of nasal coadministration of adjuvants. Immunology and Cell Biology 82, 628-637.
Panatarotto, D., Singh, R., McCarthy, D., Erhardt, M., Briand, J-P., Prato, M., Kostarelos,
K., Bianco, A., 2004. Functionalised carbon nanotubes for plasmid DNA gene delivery.
Angewandte Chemie International Edition 43, 5242-5246.
Papanicolaou, I., Briggs, S., Alpar, H.O., 2004. Increased resistance of DNA lipoplexes to
protein binding in vitro by surface-modification with a multivalent hydrophilic polymer.
Journal of Drug Targeting 12, 541- 547.
Somavarapu, S., Bramwell, V.W., Alpar, H.O., 2004. Oral plasmid DNA delivery systems
for genetic immunisation. Journal of Drug Targeting 11, 547-553.
Suitthimeathegorn, O., Jaitely, V., Florence, A.T., 2004. Exploring the possibilities of stable
anhydrous emulsions. Drug Delivery Technology 5, 52-56.
Not previously reported

Bramwell, V.W., Somavarapu, S., Outschoom, I., Alpar, H.O, 2003. Adjuvant action of
melittin following intranasal immunisation with tetanus and diphtheria toxoids. Journal of
Drug Targeting
11, 525-30.
Other output

Alpar, H.O., 2004. Strategies for vaccine delivery – Preface. Journal of Drug Targeting 11,
459-461.
Florence, A.T., 2004. The dangers of generalization in nanotechnology. Drug Discovery
Today
9, 60-61 (Letter).

DEPARTMENT OF PRACTICE AND POLICY

Barber, N., 2004. Designing information technology to support prescribing decision
making. Quality and Safety in Health Care 13, 450-454.
Barber, N., Parsons, J., Clifford, S., Darracott, R., Horne, R., 2004. Patient’s problems with
new medication for chronic conditions. Quality and Safety in Health Care 13, 172-175.
Bates, I., McRobbie, D., Davies, G., Webb, D., 2004. Why we need a defined career
structure in place of informal progression. Pharmaceutical Journal 272, 283.
Brady, D., Franklin, B.D., 2004. An evaluation of the contribution of the medical
admissions pharmacist at a London teaching hospital. International Journal of Pharmacy
Practice
12, 1-6.
Coleman, B., Martin, C., Barber, N., Patterson, D., 2004. An evaluation of the safety and
acceptability of an anticoagulation clinic in a community pharmacy setting – a pilot study.
Pharmaceutical Journal 273, 822-824.
Cooke, F., Franklin, B.D., Lawson, W., Jacklin, A., Holmes, A., 2004. Multidisciplinary
hospital antibiotic stewardship: a west London model. Clinical Governance 9, 237-243.
Costa, F., Duggan, C., van Mil, J.W.F., 2004. Assessing the pharmaceutical care needs of
asthmatic patients. Pharmacy World and Science 26, 313-318.
Costa, F., van Mil, J.W.F., Duggan, C., Mata, P.L., Caramona, M., 2004. Assessing
documentation forms for patients with asthma. Serguimiento Farmacoterapia 2, 153-171.
Crowley, C., Scott, D., Duggan, C., Whittlesea, C.M., 2004. Describing the frequency of IV
medication preparation and administration errors. Hospital Pharmacist 11, 330-336.
Davies, J.G., Webb, D.G., McRobbie, D., Bates, I.P., 2004. Consultant practice – a
strategy for practitioner development. Hospital Pharmacist 11, 2-3.
Dhillon, S., Curtis, S., 2004. Strengthening postgraduate education – a new structure for
pharmacy. Pharmaceutical Journal 273, 256-257.
Duggan, C., 2004. Good Communication and discharge reduce medication errors.
Pharmacy in Practice 14, 81-83.

Duggan C., 2004. Multi-professional collaboration: examples and experiences. Pharmacy
Education
4, 111-113.
Duggan, C., Engová, D., Franklin, B.D., Wong, I., 2004. Bridging the gap between
academia and practice. Hospital Pharmacist 11, 155-157.
Garfield, S., Francis, S-A., Smith, F.J., 2004. Building concordant relationships with
patients starting antidepressant medication. Patient Education and Counseling 55, 241-
246.

Garfield, S., Smith, F., Francis, S-A., 2004. From black clouds to lighter grey: how
pharmacists can help in depression. Pharmaceutical Journal 272, 576-577.

Jenkings, K.N., Barber, N., 2004. What constitutes evidence in hospital new drug decision
making? Social Science and Medicine 58, 1757-1766.
Joseph, A., Franklin, B.D., James, D., 2004. An evaluation of a hospital-based patient
medicines information helpline. Pharmaceutical Journal 272, 126-189.
Meadows. N., Webb, D., McRobbie, D., Antoniou, S., Bates, I., Davies, G., 2004.
Developing and validating a competency framework for advanced pharmacy practice.
Pharmaceutical Journal 273, 789-792.
Raynor, D.K., Savage, I., Knapp, P., Henley, J., 2004. We are the experts: people with
asthma talk about their medicine information needs. Patient Education and Counselling 53,
167-174.
Sadak, M.R., Stevens, C., Duggan, C., 2004. An audit of preoperative medicines in
patients undergoing surgery. Pharmacy World and Science 26, A55-56.
Shah, R., 2004. Improving undergraduate communication and clinical skills: personal
reflections of a real world experience. Pharmacy Education 4, 1-6.

Slatter, A., Francis, S., Smith, F., Bush, A., 2004. Supporting parents in managing drugs
for children with cystic fibrosis. British Journal of Nursing 13, 1135-1139.
Smith, F.J., 2004. Community pharmacy in Ghana: enhancing the contribution to primary
health care. Health Policy & Planning 19, 234-241.

Smith, F.J., 2004. Métodos de investigatión la práctica farmacéutica. Ediciones Mayo,
Barcelona.
Taxis, K., Barber, N., 2004. Causes of intravenous medication errors - observation of
nurses in a German hospital. Journal of Public Health 12, 132-138.

Taxis, K., Barber, N., 2004. Incidence and severity of intravenous drug errors in a German
hospital. European Journal of Clinical Pharmacology 59, 815-817.

Taylor, D.G., 2004. Direct to consumer advertising of prescription medicines in Europe: its
place in informing the use of pharmaceuticals. In: Asato, J. (Ed.), Direct to Patient
Communication: Patient Empowerment of NHS Burden?
The Social Market Foundation,
London.
Taylor, D.G., 2004. Regulating the prices and costs of medicines in the United Kingdom.
Journal of Pharmaceutical Finance, Economics and Policy 12, 235-260.
Taylor, D.G., Carter, S., 2004. Valuing Choice: Dying at Home. Marie Curie Cancer Care,
London.
Taylor, D.G., Carter, S., Sherman, P., 2004. Medicines Which Affect the Mind. Heritage
Care, London.
Taylor, D.G., Mrazek, M., Mossialos, 2004. Regulating pharmaceutical distribution and
retail pharmacy in Europe. In: Mossialos, E., Mrazek, M., Whalley, T. (Eds.), Regulating
Pharmaceuticals in Europe: Striving for Efficiency, Equity and Quality
. Open University
Press, Maidenhead.
Taylor, D.G., Newbould, J., 2004. Protecting the children of the new Europe. PhRMA,
Brussels.
Taylor, K.M.G., Bates, I.P., Harding, G., 2004. The implications of increasing students for
pharmacy education. Pharmacy Education 4, 33-39.
Webb, D.G., Davies, J.G., McRobbie, D., Bates, I.P., Wright, J., 2004. Adopting a strategy
for practitioner development. Hospital Pharmacist 11, 104-108.
Wong I.C.K., Ghaleb, M.A., Franklin, B.D., Barber N., 2004. Incidence and nature of
dosing errors in paediatric medications: a systematic review. Drug Safety 27, 661-670.
Wong, I.C.K., Murray, M.L., Camilleri-Novak, D., Stephens, P., 2004. Increased
prescribing trends of paediatric psychotropic medications. Archives of Disease in
Childhood
89, 1131-1132.
Worrall. S.P.R., Almond, M.K., Dhillon, S., 2004. Pharmacokinetics of bupropion and its
metabolites in haemodialysis patients who smoke: a single dose study. Nephron Clinical
Practice
97, 83-89.
Other outputs
Carter, S., Åstrom, A., 2004. A cross-sectional study of UK academics suggests Santa
Claus might be a professor. Pharmaceutical Journal 273, 897-899.

Dhillon, S., 2004. Let us strengthen postgraduate education. Pharmaceutical Journal 273,
114. [Letter]
Taxis, K., Wirtz, V., Barber, N., 2004. Variations in aseptic techniques during preparation
and administration of intravenous drugs – an observation-based study in the UK and in
Germany. Journal of Hospital Infections 56, 79-81.[Letter]

CENTRE FOR PAEDIATRIC PHARMACY RESEARCH

Bistrussu, S., Beeton, A., Castaldo, G., Han, J., Wong, I., Tuleu, C., Long, P.F., Brown, K.,
Cross, N., Cope, J., Goldman, A.P., Karimova, A., O’Callaghan, M., Robertson, A., Smith,
L., 2004. Are extracorporeal membrane oxygenation circuits that are primed with
plasmalyte and stored a likely source of infection? Journal of Clinical Microbiology 42,
3906.
Costello, I., Wong, I.C.K., Nunn, A.J., 2004. A literature review to identify interventions to
improve use of medicines in children. Child Care, Health and Development 30, 647-665.
Duggan, C., Engova, D., Franklin, B.D., Wong, I., 2004. Bridging the gap between
academia and practice. Hospital Pharmacist 11, 155-157.
Hodgson, C., Wong, I.C.K., 2004. A descriptive survey of the opinions of mothers with
young children of UK community pharmacists. Journal of Family Health Care 14, 73-79.
Li, S.C., Ong, S.C., Lim, S.G., Yeoh, K.G., Kwong, K.S., Lee, V., Lee, W., Lau, J., Wong,
I., Kung, N., Leung, W.T., Chan, H.L., Chan, F.K., Sung, J.J., Lee, K.K., 2004. A cost
comparison of management of chronic hepatitis B and its associated complications in
Hong Kong and Singapore. Journal of Clinical Gastroenterology 38, S136-143.
Murray, M.L., de Vries, C.S., Wong, I.C.K., 2004. A drug utilisation study of
antidepressants in children and adolescents using the general practice research database.
Archives of Disease in Childhood 89, 1098-1102.
Murray, M.L., Wong, I.C.K., de Vries, C.S., Shenderey, K.D., Herxheimer, A., 2004.
Treating major depression in children and adolescents. British Medical Journal 328, 524-
525.
Standing, J.F., Wong, I.C.K., 2004. Chlorproguanil-dapsone for malaria. Lancet 364, 1752-
1753.
Tuleu, C., Newton, M., Rose, J., Euler, D., Saklatvala, R., Clarke, A., Booth, S., 2004.
Comparative bioavailability study in dogs of self-emulsifying formulation of progesterone
presented in a pellet and liquid form compared with an aqueous suspension of
progesterone. Journal of Pharmaceutical Sciences 93, 1495-1502.

Wong, I.C.K., 2004. Randomised controlled trials (RCTs) to evaluate complex healthcare
interventions: a case study. Pharmacy World and Science 26, 247-252.
Wong, I.C.K., Besag, F.M.C., Santosh, P., Murray, M.L., 2004. Use of selective serotonin
reuptake inhibitors in children and adolescents. Drug Safety 27, 991-1000.
Wong, I.C.K., Awolowo, T., Gordon, K., Mo, Y.W., 2004. Survey of administration of
medicines to pupils in primary schools within the London area. Archives of Disease in
Childhood
89, 998-1001.
Wong I.C.K., Ghaleb, M.A., Franklin, B.D., Barber N., 2004. Incidence and nature of
dosing errors in paediatric medications: a systematic review. Drug Safety 27, 661-670.
Wong, I.C.K., Murray, M.L., Camilleri-Novak, D., Stephens, P., 2004. Increased
prescribing trends of paediatric psychotropic medications. Archives of Disease in
Childhood
89, 1131-1132.
Yeung, Y.W., Tuleu, C.L., Wong, I.C.K., 2004. National study of extemporaneous
preparations in English paediatric hospital pharmacies. Paediatric and Perinatal Drug
Therapy
6, 75-80.
Other outputs

Sweiss, D., Wong, I.C.K., 2004. Giving medicines to children: understanding the parent’s
views. Paediatric Drugs 6, 67-69. [Letter]
LIBRARY AND INFORMATION SERVICES

Lisgarten, L., 2004. What is pharmacy? Newsletter to European Health Librarians, 26-27.
Wake, M., 2004. Electronic IPA and EMBASE: a first glance comparison for pharmacy - a
study in progress. Newsletter to European Health Librarians, 28-33.
Hunter, T. and Wake, M. (Eds), 2004. Guide to working in health information. CILIP. HLG, London. [Online. Available from http://www.cilip.org.uk/specialinterestgroups/bysubject/health/publications/workguide] Wake, M., 2004. Internet resources for pharmacy. Newsletter to European Health Librarians, 34-35. *Full papers, reviews, chapters in books, books. Abstracts not included

Source: http://w01.ulsopcms.wf.ulcc.ac.uk/fileadmin/documents/Research/publications/StaffPublications2004.pdf

Indication

Fondation du Centre Pluridisciplinaire d’Oncologie CHUV BH 06 - Rue du Bugnon 46 - 1011 Lausanne ZOOM SAKK 65/08 Indication Advanced hematologic malignancies (multiple myeloma, acute myeloid leukemia, acute lymphoblastic leukemia, malignant lymphoma) Phase I trial of nelfinavir and bortezomib in advanced hematologic malignancies Protocol ID SAKK 65/08 SAKK (

Microsoft word - instructions for use - tadalafil.doc

Can TADALAFIL TABLET be taken simultaneously with other medicines? As a general rule, always tell your doctor if you are taking or have recently taken any other medicine, even those not prescribed, because occasionally they might interact. This is particularly important if you are treated with nitrates as you should not take TADALAFIL if you are taking these medicines. Do not take TADALAFIL wi

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