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Molecular Nutrition: A Missing Link in Pediatric Pharmacotherapy?
“Let food be thy
medicine, and medi-
reductase) impairs folic acid conversion cine be thy food”
plemental nutrients and elimination diets cure, also activates children’s genes. eating and lifestyle do not suffice to op- timize health. In assessing child and ado- lescent mental conditions, today’s envi- lecular nutrition has untapped potential been cited among the causes of illness – pesticides, air pollutants), and inflamma- on digestion, absorption, and circulation. sweets, sodas, and trans-fats, a.k.a “junk jury, diet) (Crinnion, 2009; Kroger et al., tween two “brains” (in the gut and the “SAD” (Standard American Diet). This mood, cognition, and behavior, let alone ciencies, which also affect drug utiliza- nutrition psychosocially. Food is tied to individual matter, a healthy diet template quality of the eating experience matters: is the “tone” at the dinner table? Family interactions affect the child’s vagal tone, Galle, Molecular Nutrition., continued
In pediatric nutrition, the first double blind, placebo, controlled clinical trial in the liver, contributing to intracellular took place over fifty years ago, with 120 beset the child’s daily life, GI distress lipid retention. Antipsychotic drugs that inhibit functioning of the electron trans- That research shed light on the positive haloperidol), and several atypical antip- Nutrient Deficiencies ß à Mind-
Brain-Behavior Dysfunction
The gut, our “second brain” (Gershon, 1999) contains leads to a child’s suffer- Attention Deficit/Hyperactivity Disorder IBD, UC, “leaky gut”) (Gerson et al., the liver (Neustadt & Pieczenik, 2008). (B6, B2, and B3) in seizure disorders and more from controlled clinical trials, we tant role. Thoughts and feelings set the et al., 2010). While pediatric research is ance. The brain (along with the heart) is long-term health, as well as alleviating gistically to create that energy and main- Omega 3 essential fatty acids (EFA), free acids as “add-on therapy” to mirtazapine Galle, Molecular Nutrition., continued
antidepressants are appropriate, both in rhiza glabra [licorice], Hypericum showed a higher intake of fish, EPA, and Rhodiola rosea, etc. (Head & Kelly, 2009) individualized metabolic analysis. Labora- cantly for girls) (Murakami et al., 2010). levels may not reflect nutrient function- Aphanizomenon Flos-Aquae or AFA), clude: alpha-lipoic acid, vitamin C and E, analysis reveals whether vitamins, amino n-acetylcarnitine, n-acetylcysteine, glu- acids, EFA’s, minerals, etc., are “doing their job.” For example Organic Acids, a nutrient of interest in relation to bipolar Taraxacum officinale [dandelion], Green Algae, is a natural stimulant used nents, oxidative stress, liver detox indi- metabolization, allowing its entry in the brain (Sabelli, 2002). Lithium orotate is mulative nutritional deficiencies, and the (e.g., atypical anti-psychotics, lithium). While nutrient efficacy studies are few, four meta-analyses of efficacy trials sub- ity (Sahelian, 2009). Research is needed pressants are only marginally efficacious Galle, Molecular Nutrition., continued
glutamine with co-factors) could be used behavior. This was a result of individual- ized programs consisting of diet, gentle detox, nutrients, probiotics, herbs, and (ASD), a recent review article identified stress, deficiencies in methylation, glu- particularly in the initial phases of treat- diet with children and adolescents opens Drugs utilize and may deplete nutrients, Blaylock & Struneka (2009) emphasized 1988; Montagnier et al., 2009; Tournier, Molecular nutrition addresses biological roots as it tackles individual metabolism, heal. An encouraging study involves chil- fold. First, they are constantly changing. diet and nutrients in relation to pharma- nals, etc. Test findings of abnormalities trials are sprouting, the jury is still out. metabolic causes, allowing for nutrition- ric primary care team. As scientifically ally improving neurophysiological activa- trained professionals, and at this state of tion and obtaining psychological benefits. the art, it is timely to update informed Such functional awareness is the starting The stage is set for medical/prescribing therapeutic matrix, illustrates dramatic Galle, Molecular Nutrition., continued
“in teams.” A drug, in contrast, is usually She is on the clinical faculty in Departments of Pediatrics at George Washington University tested in isolation. In addition to single Medical School (Children’s National Medical vitamin research, there is much to learn calls for caution. Firstly, nutraceuticals Center, Adolescent & Young Adult Medicine) and Georgetown University. She is on the adjunct faculty at Alliant International University, and teaches the “Introduction to Nutritional Science and Its Role in Psychopharmacology,” course in the Postdoctoral master’s in clinical psychophar- macology program. She is also on the faculty and advisory board of the British Institute of have varying levels of purity. “Medical grade” nutraceuticals tested for bioavail- References
ability are suitable for therapeutic pur- Altung, U., Pittler, M. H., Ernst, E. (2007). adjuncts at different stages of pediatric randomized clinical trials. Mayo Clinic Proceedings, 82, 69-72. Barker, J. E. (2009). Lithium orotate: The mood-enhancing mineral. Complemen- tion and quality control. Secondly, little tary Prescriptions, 2, 9-10. Bender, D. A. (2002). Introduction to nutrition and metabolism (4th edition). Miami, FL: Blaylock, R. L. & Strunecka, A. (2009). Im- central mechanism of the autism spec-trum disorders. Current Medicinal Bradstreet, J. J., Smith, S., Baral, M., & Ros- interventions of clinically relevant con- ditions associated with autism spec-trum disorders and attention deficit those cases, it is best to separate drug hyperactivity disorder. Alternative Medicine Review: A Journal of clinical Crinnion, W. J. (2009). Maternal levels of Further progress in that direction entails ment and childhood health. Alternative Medicine Review: A Journal of clinical a specialized training module. This will Therapeutics, 14, 212-223. enable the inclusion of Nutritional Phar- Davenas, E., & Benveniste, J. (1988). Human macology within the scope of practice of very dilute antiserum against IgE. Na- Nutritional medicine is gaining gravitus Frei, H., Everts, R., von Ammon, K., Kauf- Dr. Galle specializes in clinical psychology, foren- man, F., Walther, D., Hsu-Schmitz, Shu-Fang, Collengerg, M., Fuhrer, K., sic neuropsychology, psychopharmacology, clini- ers, health practitioners, and research. Hassink, R., Steinlin, M., & Thurneysen, A. cal hypnosis, and biofeedback. She is a tradi- An evidence base for pediatric nutrition tional naturopath, Board Certified clinical Nutri- tionist and Classical Homepath, Functional Medi- cine Practitioner, and Certified Yoga Instructor. Galle, Molecular Nutrition., continued
trial. Euroepan Journal of Pediatrics, 164, handbook for mental health clinicians. Kaput, J. (2004). Diet-Disease Gene Interac- Papakostas, G. I., Mischoulon, D., Shyu, I., tions. Nutrition, 20, 26-31. Katz, M., Adar Levine, A., Kol-Degani, H., & (Ed.), Simillimum: Journal of the Homeo- pathic Academy of Naturopathic Physi- major depressive disorder. American Gerber, R. (1988). Vibrational medicine: New domized controlled trial. Journal of Journal of Psychiatry, 167, 942-948. choices for healing ourselves. Santa Fe, Attention Disorders, 20, 1-20. Pelton, R., La Valle, J. B., Hawkins, E. B., & Kling, M. A., Manowitz, J. P., & Pollack, I. W. Krinsky, D. L. (2001). Drug-induced Gershon, M. D. (1999). The second brain: A nutrient depletion handbook (2nd edition). groundbreaking new understanding of concentrations after acute injections of nervous disorders of the stomach and lithium carbonate and orotate. Journal Pigott, H. E., Leventhal, A. M., Alter, G. S., & of Pharmacy and Pharmacology, 30, 368- Gerson, M. J., Gerson, C. D., Awad, R. A., Kroger, S. M., Schestler, T., Weiss, B. (2005). status of research. Psychotherapy and Dancey, C., Poitras, P., Porcelli, P., & Sabelli, H. (2002). Phenylethylamine deficit psychologists. American Psychologist, 60, body attributions. Social Science and Lord, R. S., & Bralley, J. A. (Eds.) (2008). (Eds.), Natural medications for psychiatric Laboratory evaluations for integrative and disorders (pp.83-110). Baltimore, MD: Gillies, P. J. (2003). Nutrigenomics: The functional medicine (2nd edition). Du- rubicon of molecular nutrition. Journal Sahelian, J. (2009). Review of Lithium oro- of the American Dietetic Association, 103, Malkesman, O., Asaf, T., Shbiro, L., Gold- cokinetics and polyuria in rats. In British Greenberg, R. P. (2010). Prescriptive au- Journal of Pharmacology, 56, 399-402. G., & Weller, A. (2009). Monoamines, Sen, B. (2010). The relationship between tions. American Psychologist, 65, 136- Gregory, J. E., Paxton, S. J. & Brozovic, A. M. sion: An animal model study. Advances for other family characteristics. Journal in Pharmacological Sciences, 20, 1-11. Meguid, N. A., Hashish, A. F., Amar M., Sid- Stahl, S. M. (2007). Novel therapeutics for prospective analysis. The International Journal of Behavioral Nutrition and Physi- sant-augmenting agent. CNS Spectrum, with autism. Journal of Alternative and Head, K. & Kelly, G. (2009). Nutrients and Complementary Medicine, 16, 641-645. Stargrove, M. B., Treasure, J., & McKee, D. L. Montagnier, L., & Aaissa, J. (2009). Electro- (2009). Herb, nutrient, and drug interac- tions: clinical implications and therapeutic Alternative Medicine Review: A Journal of terial DNA sequences. Interdisciplinary clinical Therapeutics, 14, 114-140. Science and Computer Life Science. Tournier, A. (2008). The structure of water. Hoffer, A. (1999). Dr. Hoffer’s ABC of natural Murakami, K., Davidson, P., & Bhatia (2010). Homeopathic Research Institute Newslet- nutrition for children. Kingston, Ontario: Tournier, A. (2010). A new quantum theory Ille, R., Spona, J., Zickl, M., Hofmann, P., La- to explain homeopathy. Homeopathic National Institutes of Mental Health (NIMH) Research Institute Newsletter, 7, 1. siba, K, Mahnert, F. A., & Kapfhammer, Werbach, M. R. (1991). Nutritional influences on mental illness: A sourcebook of clinical individualized preparation consisting of bipolar disorder. clinical Trials. Gov (8- research. Tarzana, CA: Third Line major depression. European Archives of Neustadt, J. and Pieczenik, S. R. (2008). Psychiatry and clinical Neuroscience, 257, damage and disease. Molecular Nutrition tion, and botanical medicine. Profes- Kapalka, G. M. (2010). Nutritional and herbal sional Psychology: Research and Practice, therapies for children and adolescents: A Nieper, H.A. (1973). The clinical applica-

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