SYNTHESE DE LA LIDOCAÏNE Lire le protocole suivant extrait du Journal of Chemical Education (Vol 76. No. 11 November 1999). The Preparation of Lidocaine - Thomas J. Reilly Department of Chemistry and Biochemistry, Loyola Marymount University, 7900 Loyola Blvd., Los Angeles, CA 90045-8225; email@example.com This synthesis of 2-(diethylamino)-N-(2,6-dimethyl-phenyl)acetamide, comm
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Date of Issue: July, 2001
MATERIAL SAFETY DATA SHEET
STATEMENT OF HAZARDOUS NATURE:
Hazardous according to the criteria of NOHSC Australia
Syngenta Crop Protection Pty Limited
Telephone No.: (02) 9688 0444
24 Hours Emergency No.: 1 800 033 111
140-150 Bungaree Rd.,
PENDLE HILL, NSW, 2145
Ambush EC Insecticide
Dangerous goods class:
Insecticide for the control of certain insect pests.
Solubility in water:
Permethrin 40:60 (technical grade)
HEALTH HAZARD INFORMATION
This product is harmful according to NOHSC Australia.
Tests on rats indicate this product is HARMFUL following a single dose of the active
(LD50 = 806 mg/kg - male; 814 mg/kg - female)
Tests on rabbits indicate this product is NOT HARMFUL following skin contact with
(LD50 = > 2000 mg/kg)
Tests on rats indicate this product is HARMFUL due to inhalation of active ingredient.
(LC50 = 2.3 mg/L/4 hours)
AMBUSH EC INSECTICIDE
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Repeated or prolonged skin contact may lead to allergic contact dermatitis. Facial skin
contact may cause temporary facial skin numbness.
No case of human poisoning due to this product is on record. Symptoms that may arise if the product is
mishandled are nausea, vomiting, diarrhoea and in cases of severe poisoning central nervous system
depression, leading to tremors, convulsions and coma, due to the hydrocarbon solvent.
CHRONIC TOXICITY (Active Ingredient)
Permethrin technical has been extensively tested in mammals and in test-tube systems. No evidence of
mutagenic, carcinogenic, neurotoxic, teratogenic or reproductive effects was obtained. Short term tests have
shown that it is unlikely to be a carcinogenic hazard to man. Studies in animals have shown that repeated doses
produce no significant effects.
The aromatic petroleum hydrocarbon liquid may cause central nervous system depression and narcosis.
In case of poisoning by any exposure route contact a doctor or Poisons Information Centre. Phone 13 11 26.
If poisoning occurs contact a doctor or Poisons Information Centre. DO NOT induce vomiting.
Give a glass of water.
Will damage the eyes. Avoid contact with eyes. If product gets in eyes wash it out immediatelywith copious quantities of water for 15 minutes.
Will irritate the skin. Avoid contact with skin. If skin contact occurs remove contaminated clothingand wash affected areas thoroughly with soap and water. Wash contaminated clothing before re-use. If swelling, redness, blistering or irritation occurs seek medical advice.
Move person to fresh air and keep at rest until recovered. Remove any contamined clothing andloosen remaining clothing. Allow patient to assume most comfortable position and keep warm. Ifbreathing laboured and patient cyanotic (blue) ensure airways are clear and have qualified persongive oxygen through a face mask. If breathing has stopped, apply artificial respeiration at once. Inevent of cardiac arrest, apply external cardiac massage. If any signs or symptoms occur orpersist, get medical attention.
ADVICE TO DOCTOR
No specific antidote exists. Treat symptomatically.
PRECAUTIONS FOR USE
ALWAYS READ AND FOLLOW THE LABEL INSTRUCTIONS AND WARNINGS
TWA = The time weighted average airborne concentrations over an eight-hour working day, for a five-day working week over an entire working life.
Exposure Potential -
Swallowing is unlikely under normal conditions of usage. Significant skin uptake does not occur. Inhalation is a possible route of exposure. This product is diluted with water prior to use as a spray. This
diluted form is less toxic by all routes of exposure.
Re-entry Period -
Do not enter treated areas without protective clothing for 12 hours after application.
No special requirements. Product is used outdoors. Ensure ventilation is adequate and that air concentrations of
components are controlled below quoted Exposure Standards. Keep containers closed when not in use.
For space applications, wear elbow-length PVC gloves and face shield.
Poisonous if swallowed. Will damage eyes and irritate the skin. Avoid contact with eyes and skin. Do not inhale
spray mist. When opening the container and preparing spray wear elbow-length PVC gloves and face shield. When
using prepared spray wear elbow-length PVC gloves and face shield. If product in eyes, wash it out immediately
with water. After use and before eating, drinking or smoking, wash hands, arms and face thoroughly with soap and
water. After each day’s use, wash gloves, face shield and contaminated clothing.
Only use protective equipment bearing the mark of the Standards Association of Australia.
AMBUSH EC INSECTICIDE
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This product is a combustible liquid.
SAFE HANDLING INFORMATION
STORAGE AND TRANSPORT
Store in closed, original container in a dry cool, well-ventilated area out of direct sunlight. Keep out of reach of
children, unauthorised persons and animals.
Store and transport according to the requirements for a Class 9 dangerous good and a Schedule 6 poison.
Transport Classification – Sea (IMDG):
Proper Shipping Name:
Not to be loaded with explosives.
SPILLS AND DISPOSAL
In case of spillage it is important to take all steps necessary to:
• Avoid contamination of waterways.
• Shut off all possible sources of ignition. DO NOT smoke.
Procedure for spill:
Wear full length clothing and PVC gloves.
Re-position any leaking containers so as to minimise further leakage.
Dam and absorb spill with an absorbent material (e.g. sand or soil).
Shovel the absorbed spill into drums.
Disposal of the absorbed material will depend upon the extent of the spill.
• For quantities up to 50L of product bury in a secure landfill site.
• For quantities greater than 50L seek advice from the manufacturer (use emergency contact number below) before attempting disposal. Contain in a secure location until disposal method is established.
(7) Decontaminate the spill area with detergent and water and rinse with the smallest volume of water practicable.
Dispose of empty, used containers by:
Triple rinsing or preferably pressure rinsing containers with water. Add the rinsings to the spray tank. DO NOTdispose of undiluted chemicals on site.
If recycling, replace cap and return clean containers to recycler or designated collection point.
(c) If not recycling, break, crush or puncture and bury empty containers in a local authority landfill. If no landfill is available, bury the containers below 500 mm in a disposal pit specifically marked and set up for this purposeclear of waterways, desirable vegetation and tree roots. Empty containers and product should not be burnt.
This product is combustible. Keep containers cool with water spray. Extinguish warehouse and factory fires using
water fog (if unavailable use fine water-spray), foam, dry agent (carbon dioxide, dry chemical powder). During a fire
this product may release smoke and hazardous decomposition products. When fighting a major fire wear SCBA and
structural firefighters uniform. Do not allow fire-water to enter drains.
The active ingredient Permethrin is very toxic to aquatic organisms. Contamination of waterways should be strictly
avoided. DO NOT apply under weather conditions or from spraying equipment which could be expected to cause
spray to drift onto adjacent areas, particularly streams, rivers or other waterbodies.
Rainbow Trout, Oncorhynchus mykiss , LC50 (96 h) = 2.5 µg/L; LC50 (48 h) = 5.4 µg/LWater Flea, Daphnia magna, LC50 (48 h) = 0.6 µg/LBluegill Sunfish, LC50 (48 h) = 1.8 µg/L Permethrin is toxic to bees (LD50 (24h) = 0.098 µg/bee) and practically non-toxic to birds (Chicken: LD50 = >3000mg/kg; Japanese Quail: LD50 = >13,500 mg/kg).
This substance has low mobility in the soil. It has a high potential for bioaccumulation but is rapidly eliminated fromfish (about 80% in 14 days). There is evidence of degradation in soil and water. The half life in soil is less than 38days.
AMBUSH EC INSECTICIDE
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This product is a registered agricultural chemical and must therefore be used in accordance with the container label directions. A
comprehensive package of toxicological and environmental data for the active ingredients of this product has been submitted to the
Federal health and environment authorities and has been evaluated by expert toxicologists and environmental scientists.
Regulatory Affairs Manager - Crop Protection - (02) 9688 0444 24 HOURS EMERGENCY CONTACT:
1 800 033 111
This Material Safety Data Sheet summarises our best knowledge of the health and safety hazard information of the product and how to safely
handle and use the product in the workplace. Each user should read this MSDS and consider the information in the context of how the
product will be handled and used in the workplace including in conjunction with other products.
If clarification or further information is needed to ensure that an appropriate risk assessment can be made, the user should contact this
Collated by HerbiGuide. Phone 08 98444064 for more information.
Quantitative LC-MS: “How Certain Can we be!”Peter Stokes, Gavin O’Connor, Chris Mussell, & Ken WebbLGC Limited, Queens Rd. Teddington, Middlesex, TW11 0LY. INTRODUCTION THE ANALYSIS OF CREATININE IN HUMAN SERUM CREATININE MEASUREMENTS USING DIFFERENT Less than 20% of all LC-MS publications involve MASS SPECTROMETRIC TECHNIQUES quantitation. The reasons for the slow