Li Pan, MS,1 Ahmed S. Fahmy, MS,2 Amy Spooner, MD,1
Robert G. Weiss, MD,1 Matthias Stuber, PhD,1 Nael F.
Osman, PhD.1 1Johns Hopkins School of Medicine, Bal-
timore, MD, USA,
2Johns Hopkins University, Baltimore,

(a) Longitudinal strain measurments by segments in short-axis view Introduction: SENC imaging (1) is a technique that can directly from one patient. (b) The eight segments defined clockwise in the short-axis image and quantify regional myocardial function. It has been view, shown on the SSFP image, with the isertion point of the right ventricle demonstrated that SENC imaging on a 3T system provides sim- (green spot) as mid-point of the first segment.
ilar strain measurements in normal subjects as those acquired at1.5T and offers improvements in SNR (2). In this study, SENC travenous contrast, 0.2−1Gd-DTPA, was injected. Fif- imaging sequences, implemented on 3T MR scanner, have been teen minutes later, an inversion-recovery (IR)-prepared, fast field used to study patients with a history of myocardial infarction.
echo (FFE) pulse sequence with inversion time (TI) = 300 ms The dysfunctional regions detected by SENC acquisition have was performed to obtain a delayed enhancement image for the been compared with those identified by delayed enhancement Results: Fig. 1 shows representative results of SENC imaging Purpose: To demonstrate that SENC imaging can provide from two patients, each row represents a different patient. In both reliable evaluation of regional dysfunction of the heart in patients four-chamber and short-axis views, the comparison of the areas with a history of myocardial infarction on a 3T MR scanner.
of myocardial dysfunction detected by SENC imaging (Fig. 1 Methods: Following informed consent, the studies were per- b,d,f,h) to the nonviable myocardium defined by hyperenhanced formed on a clinical 3T MR whole body scanner (Achieva, tissue in the delayed enhancement images (Fig. 1 a,c,e,g) shows Philips Medical System, Best, The Netherlands). Five patients high agreement. Fig. 2a shows representative results of longitu- (four males, one female) with a history of myocardial infarction dinal strain measurements of eight segments, defined in Fig. 2b, were imaged in both short-axis and four-chamber views. SENC on short-axis SENC images. Segments 5,6,7 are infarcted re- images were acquired in one breath-hold with low-tuning and gions, which show no contraction, segments 3,4,8 are adjacent high-tuning interleaved in one acquisition. A total of 19 to 23 regions, which show reduced contraction, and segments 1,2 are time frames were acquired to cover systole. The tuning spa- remote non-infarcted regions, which show normal contraction.
tial frequencies were set as 0.3 mm−1 and 0.4 mm−1 for low- Conclusions: Despite the inherent challenges for cardiac tuning and high-tuning respectively. The imaging parameters imaging at 3T, the SENC imaging has been demonstrated to were: slice thickness = 10 mm, FOV = 350 mm, matrix size = be able to detect the regional dysfunction of the heart in pa- 176 × 176, spiral interleaves = 12, spiral acquisition window = tients with a history of myocardial infarction. The identified 12 ms, max ramped flip angle = 40. After SENC acquisition, in- dysfunctional regions show high agreement with those defined Representative results from two patients (patient 1: first row, patient 2: second row) in both four-chamber (first two columns) and short-axis view (last two columns). The SENC functional images (b,d,f,h) showing regional dysfunction (arrows) were compared with the delayed-enhancement images (a,c,e,g) showinghyperenhanced nonviable infarcted myocardium (arrows).
by delayed enhancement imaging. SENC imaging on 3T MR system allows determination of regional myocardial function, with high spatial resolution, in infarcted, adjacent, and remotehuman myocardium.
Acknowledgements: This research was supported by grant RO1 HL072704 and by support from the Donald W. Reynolds REFERENCES
1. Osman NF, et al. Magn Reson Med 2001;46:324–334.
2. Pan L, et al. SCMR 2005, #397.
Brett R. Cowan, BE MbChB, Alistair A. Young, BE ME PhD,
on behalf of the ONTARGET MRI Substudy Investigators.
University of Auckland, Auckland, New Zealand.

informed consent, uncontrolled hypertension on treatment, hearttransplant or stroke due to subarachnoid haemorrhage (1). Sub- Introduction: ONTARGET (ONgoing Telmisartan Alone and study exclusion criteria included MRI contraindications. Writ- in combination with Ramipril Global Endpoint Trial) is a world- ten informed consent was obtained from all subjects and regula- wide, multi-center, controlled clinical trial investigating the ef- tory authorities of local participating institutions in all countries fects of ramipril and the angiotensin II receptor blocker telmisar- approved the study protocol. The MR imaging protocol was tan, alone and in combination, in high-risk subjects with vascular standardized across 8 imaging centers. Subjects were imaged disease (1). Major cardiovascular events are being assessed to for the baseline examination during week 3 (plus or minus 1 test for reduction in composite outcome (1). In order to investi- week) of the run in phase of the trial (ie an average of one week gate mechanistic pathways in these therapies, a MRI substudy prior to randomization and commencement on study medica- will determine whether the effects of these agents involve direct tion). Steady state free precession anatomical cine images were actions on LV mass and volume, as determined by MRI.
acquired in six equally spaced short axis locations from apex Purpose: i) To report the baseline characteristics for subjects to base and three long axis slices orthogonal to the short axis enrolled in the MRI substudy to ONTARGET. ii) To examine and orientated at 60 degree increments about the central axis differences in LV mass and volumes between Asian and non- of the LV. Typical imaging parameters were TR/TE/flip/FOV = 30 ms/1.6 ms/60◦/360 mm, slice thickness 6 mm, image matrix Methods: The Cardiac MRI substudy to ONTARGET com- 256 × 208, 25 frames reconstructed, 8–15 sec breath-hold du- prised 28 recruiting centers in 6 countries (Australia, New ration. All MRI studies were digitally recorded onto CD-ROM Zealand, Germany, Canada, Thailand and Hong Kong); 330 and sent to the core lab for analysis. LV mass and volumes were patients were enrolled between October 2002 and July 2003.
determined using guide point modelling (2).
Patients were included with myocardial infarction (MI), coro- Results: Table 1 shows basic patient characteristics. LV mass nary or peripheral arterial disease (CAD, PAD), cerebrovascular and volumes are shown in Table 2. LV mass, EDV and ESV disease (CVD) or high-risk diabetes mellitus (DM) with end- were smaller in Asians vs non-Asians (p < 0.001 for each).
organ damage (1). Patients were excluded with symptomatic However, on normalization with the allometric index Height2.7, congestive heart failure, significant valvular disease, complex the differences between ethnic groups wereas eliminated (p = congenital heart disease, syncopal episodes of unknown aetiol- ogy, planned cardiac surgery or PTCA within three months of Conclusion: Baseline characteristics for the MRI substudy to ONTARGET cover a wide range of patient diagnoses. LV mass and volume measurements from these patients provide useful data on population variation in cardiovascular disease.
The allometric index Height2.7 normalized LV mass and volumes between Asian and non-Asian cohorts.
1. Teo KK, et al. Am Heart J 2004;148:52–61.
2. Young AA, et al. Radiology 2000; 216:597–602.



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