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Annex i

SUMMARY OF PRODUCT CHARACTERISTICS
NAME OF THE MEDICINAL PRODUCT

Leflunomide medac 10 mg film-coated tablets
2.
QUALITATIVE AND QUANTITATIVE COMPOSITION
Each film-coated tablet contains 10 mg of leflunomide. Excipients with known effect: Each film-coated tablet contains 76 mg of lactose (as monohydrate) and 0.06 mg of soya lecithin.
For the full list of excipients, see section 6.1.
3.
PHARMACEUTICAL FORM

Film-coated tablet.
White to almost white, round film-coated tablet with a diameter of about 6 mm.
4.
CLINICAL PARTICULARS
Therapeutic indications
Leflunomide is indicated for the treatment of adult patients with: active rheumatoid arthritis as a "disease-modifying antirheumatic drug" (DMARD). Recent or concurrent treatment with hepatotoxic or haematotoxic DMARDs (e.g. methotrexate) may result in an increased risk of serious adverse reactions; therefore, the initiation of leflunomide treatment has to be carefully considered regarding these benefit/risk aspects. Moreover, switching from leflunomide to another DMARD without following the washout procedure
(see section 4.4) may also increase the risk of serious adverse reactions even for a long time after the
switching.
4.2
Posology and method of administration

The treatment should be initiated and supervised by specialists experienced in the treatment of
rheumatoid arthritis.
Alanine aminotransferase (ALT) (orserum glutamopyruvate transferase SGPT) and a complete blood cell count, including a differential white blood cell count and a platelet count, must be checked simultaneously and with the same frequency: every two weeks during the first six months of treatment, and every 8 weeks thereafter (see section 4.4). In rheumatoid arthritis: leflunomide therapy is usually started with a loading dose of 100 mg once daily for 3 days. Omission of the loading dose may decrease the risk of adverse events (see section 5.1). The recommended maintenance dose is leflunomide 10 mg to 20 mg once daily depending on the severity (activity) of the disease. The therapeutic effect usually starts after 4 to 6 weeks and may further improve up to 4 to 6 months. There is no dose adjustment recommended in patients with mild renal insufficiency. No dosage adjustment is required in patients above 65 years of age.
Paediatric population

Leflunomide medac is not recommended for use in patients below 18 years since efficacy and safety in
juvenile rheumatoid arthritis (JRA) have not been established (see sections 5.1 and 5.2).
Method of administration
Leflunomide medac tablets should be swallowed whole with sufficient amounts of liquid. The extent
of leflunomide absorption is not affected if it is taken with food.

4.3

Contraindications
Hypersensitivity to the active substance (especially previous Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme), peanut or soya or to any of the excipients listed in section 6.1., Patients with impairment of liver function, Patients with severe immunodeficiency states, e.g. AIDS, Patients with significantly impaired bone marrow function or significant anaemia, leucopenia, neutropenia or thrombocytopenia due to causes other than rheumatoid, Patients with serious infections (see section 4.4), Patients with moderate to severe renal insufficiency, because insufficient clinical experience is available in this patient group, Patients with severe hypoproteinaemia, e.g. in nephrotic syndrome, Pregnant women, or women of childbearing potential who are not using reliable contraception during treatment with leflunomide and thereafter as long as the plasma levels of the active metabolite are above 0.02 mg/l (see section 4.6). Pregnancy must be excluded before start of treatment with leflunomide, Special warnings and precautions for use

Concomitant administration of hepatotoxic or haematotoxic DMARDs (e.g. methotrexate) is not
advisable.
The active metabolite of leflunomide, A771726, has a long half-life, usually 1 to 4 weeks. Serious
undesirable effects might occur (e.g. hepatotoxicity, haematotoxicity or allergic reactions, see below),
even if the treatment with leflunomide has been stopped. Therefore, when such toxicities occur or if
for any other reason A771726 needs to be cleared rapidly from the body, the washout procedure has to
be followed. The procedure may be repeated as clinically necessary.
For washout procedures and other recommended actions in case of desired or unintended pregnancy, see section 4.6. Liver reactions Rare cases of severe liver injury, including cases with fatal outcome, have been reported during treatment with leflunomide. Most of the cases occurred within the first 6 months of treatment. Co-treatment with other hepatotoxic medicinal products was frequently present. It is considered essential that monitoring recommendations are strictly adhered to. ALT (SGPT) must be checked before initiation of leflunomide and at the same frequency as the complete blood cell count (every two weeks) during the first six months of treatment and every 8 weeks thereafter. For ALT (SGPT) elevations between 2- and 3-fold the upper limit of normal, dose reduction from 20 mg to 10 mg may be considered and monitoring must be performed weekly. If ALT (SGPT) elevations of more than 2-fold the upper limit of normal persist or if ALT elevations of more than 3-fold the upper limit of normal are present, leflunomide must be discontinued and wash-out procedures initiated. It is recommended that monitoring of liver enzymes be maintained after discontinuation of leflunomide treatment, until liver enzyme levels have normalised. Due to a potential for additive hepatotoxic effects, it is recommended that alcohol consumption be avoided during treatment with leflunomide. Since the active metabolite of leflunomide, A771726, is highly protein bound and cleared via hepatic metabolism and biliary secretion, plasma levels of A771726 are expected to be increased in patients with hypoproteinaemia. Leflunomide medac is contraindicated in patients with severe hypoproteinaemia or impairment of liver function (see section 4.3). Haematological reactions Together with ALT, a complete blood cell count, including differential white blood cell count and platelets, must be performed before start of leflunomide treatment as well as every 2 weeks for the first 6 months of treatment and every 8 weeks thereafter. In patients with pre-existing anaemia, leucopenia, and/or thrombocytopenia as well as in patients with impaired bone marrow function or those at risk of bone marrow suppression, the risk of haematological disorders is increased. If such effects occur, a washout (see below) to reduce plasma levels of A771726 should be considered. In case of severe haematological reactions, including pancytopenia, Leflunomide medac and any concomitant myelosuppressive treatment must be discontinued and a leflunomide washout procedure initiated. Combinations with other treatments The use of leflunomide with antimalarials used in rheumatic diseases (e.g. chloroquine and hydroxychloroquine), intramuscular or oral gold, D-penicillamine, azathioprine and other immunosuppressive agents including Tumour Necrosis Factor alpha-Inhibitors has not been adequately studied up to now in randomised trials (with the exception of methotrexate, see section 4.5). The risk associated with combination therapy, in particular in long-term treatment, is unknown. Since such therapy can lead to additive or even synergistic toxicity (e.g. hepato- or haematotoxicity), combination with another DMARD (e.g. methotrexate) is not advisable. Caution is advised when leflunomide is given together with drugs, other than NSAIDs, metabolised by CYP2C9 such as phenytoin, warfarin, phenprocoumon and tolbutamide. Switching to other treatments As leflunomide has a long persistence in the body, a switching to another DMARD (e.g. methotrexate) without performing the washout procedure (see below) may raise the possibility of additive risks even for a long time after the switching (i.e. kinetic interaction, organ toxicity). Similarly, recent treatment with hepatotoxic or haematotoxic medicinal products (e.g. methotrexate) may result in increased side effects; therefore, the initiation of leflunomide treatment has to carefully be considered regarding these benefit/risk aspects and closer monitoring is recommended in the initial phase after switching. Skin reactions In case of ulcerative stomatitis, leflunomide administration should be discontinued. Very rare cases of Stevens Johnson syndrome or toxic epidermal necrolysis have been reported in patients treated with leflunomide. As soon as skin and/or mucosal reactions are observed which raise the suspicion of such severe reactions, Leflunomide medac and any other possibly associated treatment must be discontinued, and a leflunomide washout procedure initiated immediately. A complete washout is essential in such cases. In such cases re-exposure to leflunomide is contra-indicated (see section 4.3). Pustular psoriasis and worsening of psoriasis have been reported after the use of leflunomide. Treatment withdrawal may be considered taking into account patient’s disease and past history. Infections It is known that medicinal products with immunosuppressive properties - like leflunomide - may cause patients to be more susceptible to infections, including opportunistic infections. Infections may be more severe in nature and may, therefore, require early and vigorous treatment. In the event that severe, uncontrolled infections occur, it may be necessary to interrupt leflunomide treatment and administer a washout procedure as described below. Rare cases of Progressive Multifocal Leukoencephalopathy (PML) have been reported in patients receiving leflunomide among other immunosuppressants. The risk of tuberculosis should be considered. A tuberculin reaction test should be considered for those patients with other tuberculosis risk factors. Respiratory reactions Interstitial lung disease has been reported during treatment with leflunomide (see section 4.8). The risk of its occurrence is increased in patients with a history of interstitial lung disease. Interstitial lung disease is a potentially fatal disorder, which may occur acutely during therapy. Pulmonary symptoms, such as cough and dyspnoea, may be a reason for discontinuation of the therapy and for further investigation, as appropriate. Peripheral Neuropathy Cases of peripheral neuropathy have been reported in patients receiving Leflunomide medac. Most patients improved after discontinuation of Leflunomide medac. However there was a wide variability in final outcome, i.e. in some patients the neuropathy resolved and some patients had persistent symptoms. Age older than 60 years, concomitant neurotoxic medications, and diabetes may increase
the risk for peripheral neuropathy. If a patient taking Leflunomide medac develops a peripheral
neuropathy, consider discontinuing Leflunomide medac therapy and performing the drug elimination
procedure (see section 4.4).
Blood pressure
Blood pressure must be checked before the start of leflunomide treatment and periodically thereafter.
Procreation (recommendations for men)
Male patients should be aware of the possible male-mediated foetal toxicity. Reliable contraception
during treatment with leflunomide should also be guaranteed.
There are no specific data on the risk of male-mediated foetal toxicity. However, animal studies to
evaluate this specific risk have not been conducted. To minimise any possible risk, men wishing to
father a child should consider discontinuing use of leflunomide and taking colestyramine 8 g 3 times
daily for 11 days or 50 g of activated powdered charcoal 4 times daily for 11 days.
In either case the A771726 plasma concentration is then measured for the first time. Thereafter, the
A771726 plasma concentration must be determined again after an interval of at least 14 days. If both
plasma concentrations are below 0.02 mg/l, and after a waiting period of at least 3 months, the risk of
foetal toxicity is very low.
Washout procedure
Colestyramine 8 g is administered 3 times daily. Alternatively, 50 g of activated powdered charcoal is
administered 4 times daily. Duration of a complete washout is usually 11 days. The duration may be
modified depending on clinical or laboratory variables.
Lactose

Leflunomide medac contains lactose. Patients with rare hereditary problems of galactose intolerance,
the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicinal product.
Soya lecithin

Leflunomide medac contains soya lecithin. If a patient is hypersensitive to peanut or soya,
Leflunomide medac must not be used.
4.5
Interaction with other medicinal products and other forms of interaction
Interactions studies have only been performed in adults. Increased side effects may occur in case of recent or concomitant use of hepatotoxic or haematotoxic drugs or when leflunomide treatment is followed by such drugs without a washout period (see also guidance concerning combination with other treatments, section 4.4). Therefore, closer monitoring of liver enzymes and haematological parameters is recommended in the initial phase after switching. In a small (n=30) study with co-administration of leflunomide (10 to 20 mg per day) with methotrexate (10 to 25 mg per week) a 2- to 3-fold elevation in liver enzymes was seen on 5 of 30 patients. All elevations resolved, 2 with continuation of both drugs and 3 after discontinuation of leflunomide. A more than 3-fold increase was seen in another 5 patients. All of these also resolved,2 with continuation of both drugs and 3 after discontinuation of leflunomide. In patients with rheumatoid arthritis, no pharmacokinetic interaction between the leflunomide (10 to 20 mg per day) and methotrexate (10 to 25 mg per week) was demonstrated. It is recommended that patients receiving leflunomide are not treated with colestyramine or activated powdered charcoal because this leads to a rapid and significant decrease in plasma A771726 (the active metabolite of leflunomide; see also section 5) concentration. The mechanism is thought to be by interruption of enterohepatic recycling and/or gastrointestinal dialysis of A771726. If the patient is already receiving nonsteroidal anti-inflammatory drugs (NSAIDs) and/or corticosteroids, these may be continued after starting leflunomide. The enzymes involved in the metabolism of leflunomide and its metabolites are not exactly known. An in vivo interaction study with cimetidine (non-specific cytochrome P450 inhibitor) has demonstrated a lack of a significant interaction. Following concomitant administration of a single dose of leflunomide to subjects receiving multiple doses of rifampicin (non-specific cytochrome P450 inducer) A771726 peak levels were increased by approximately 40 %, whereas the AUC was not significantly changed. The mechanism of this effect is unclear. In vitro studies indicate that A771726 inhibits cytochrome P4502C9 (CYP2C9) activity. In clinical trials no safety problems were observed when leflunomide and NSAIDs metabolised by CYP2C9 were co-administered. Caution is advised when leflunomide is given together with drugs, other than NSAIDs, metabolised by CYP2C9 such as phenytoin, warfarin, phenprocoumon and tolbutamide. In a study in which leflunomide was given concomitantly with a triphasic oral contraceptive pill containing 30 μg ethinyloestradiol to healthy female volunteers, there was no reduction in
contraceptive activity of the pill, and A771726 pharmacokinetics were within predicted ranges.
Vaccinations
No clinical data are available on the efficacy and safety of vaccinations under leflunomide treatment.
Vaccination with live attenuated vaccines is, however, not recommended. The long half-life of
leflunomide should be considered when contemplating administration of a live attenuated vaccine after
stopping Leflunomide medac.
4.6
Fertility, pregnancy and lactation
Pregnancy The active metabolite of leflunomide, A771726 is suspected to cause serious birth defects when administered during pregnancy. Leflunomide medac is contraindicated in pregnancy (see section 4.3). Women of childbearing potential have to use effective contraception during and up to 2 years after treatment (see “waiting period” below) or up to 11 days after treatment (see abbreviated “washout period” below). The patient must be advised that if there is any delay in onset of menses or any other reason to suspect pregnancy, they must notify the physician immediately for pregnancy testing, and if positive, the physician and patient must discuss the risk to the pregnancy. It is possible that rapidly lowering the blood level of the active metabolite, by instituting the drug elimination procedure described below, at the first delay of menses may decrease the risk to the foetus from leflunomide. In a small prospective study in women (n=64) who became inadvertently pregnant while taking leflunomide for no more than three weeks after conception and followed by a drug elimination procedure, no significant differences (p=0.13) were observed in the overall rate of major structural defects (5.4 %) compared to either of the comparison groups (4.2 % in the disease matched group [n=108] and 4.2 % in healthy pregnant women [n=78]). For women receiving leflunomide treatment and who wish to become pregnant, one of the following procedures is recommended in order to ascertain that the foetus is not exposed to toxic concentrations of A771726 (target concentration below 0.02 mg/l): Waiting period A771726 plasma levels can be expected to be above 0.02 mg/l for a prolonged period. The concentration may be expected to decrease below 0.02 mg/l about 2 years after stopping the treatment with leflunomide. After a 2-year waiting period, the A771726 plasma concentration is measured for the first time. Thereafter, the A771726 plasma concentration must be determined again after an interval of at least 14 days. If both plasma concentrations are below 0.02 mg/l no teratogenic risk is to be expected. For further information on the sample testing please contact the Marketing Authorisation Holder or its local representative (see section 7). Washout procedure After stopping treatment with leflunomide: colestyramine 8 g is administered 3 times daily for a period of 11 days, alternatively, 50 g of activated powdered charcoal is administered 4 times daily for a
However, also following either of the washout procedures, verification by 2 separate tests at an
interval of at least 14 days and a waiting period of one-and-a-half months between the first occurrence
of a plasma concentration below 0.02 mg/l and fertilisation is required.
Women of childbearing potential should be told that a waiting period of 2 years after treatment
discontinuation is required before they may become pregnant. If a waiting period of up to
approximately 2 years under reliable contraception is considered unpractical, prophylactic institution
of a washout procedure may be advisable.
Both colestyramine and activated powdered charcoal may influence the absorption of oestrogens and
progestogens such that reliable contraception with oral contraceptives may not be guaranteed during
the washout procedure with colestyramine or activated powdered charcoal. Use of alternative
contraceptive methods is recommended.
Breast-feeding
Animal studies indicate that leflunomide or its metabolites pass into breast milk. Breast-feeding
women must, therefore, not receive leflunomide.

4.7
Effects on ability to drive and use machines

In the case of side effects such as dizziness the patient's ability to concentrate and to react properly
may be impaired. In such cases patients should refrain from driving cars and using machines.
4.8
Undesirable effects
Summary of the safety profile

The most frequently reported adverse effects with leflunomide are: mild increase in blood pressure,
leucopenia, paraesthesia, headache, dizziness, diarrhoea, nausea, vomiting, oral mucosal disorders
(e.g. aphthous stomatitis, mouth ulceration), abdominal pain, increased hair loss, eczema, rash
(including maculo-papular rash), pruritus, dry skin, tenosynovitis, CPK increased, anorexia, weight
loss (usually insignificant), asthenia, mild allergic reactions and elevation of liver parameters
(transaminases [especially ALT], less often gamma-GT, alkaline phosphatise, bilirubin).
Classification of expected frequencies:
Very common (≥1/10); common (≥1/100 to <1/10); uncommon (≥1/1,000 to <1/100); rare (≥1/10,000
to <1/1,000); very rare (<1/10,000), not known (cannot be estimated from the available data).
Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.
Infections and infestations
Rare:
severe infections, including sepsis which may be fatal Like other agents with immunosuppressive potential, leflunomide may increase susceptibility to infections, including opportunistic infections (see also section 4.4). Thus, the overall incidence of infections can increase (in particular of rhinitis, bronchitis and pneumonia). Neoplasms benign, malignant and unspecified (incl cysts and polyps) The risk of malignancy, particularly lymphoproliferative disorders, is increased with use of some immunosuppressive agents. Blood and lymphatic system disorders Common: anaemia, mild thrombocytopenia (platelets <100 G/l) pancytopenia (probably by antiproliferative mechanism), leucopenia (leucocytes <2 G/l), eosinophilia Recent, concomitant or consecutive use of potentially myelotoxic agents may be associated with a higher risk of haematological effects. Immune system disorders Common: severe anaphylactic/anaphylactoid reactions, vasculitis, including cutaneous necrotizing vasculitis Metabolism and nutrition disorders Common: hypokalaemia, hyperlipidemia, hypophosphataemia Nervous system disorders Common: paraesthesia, headache, dizziness, peripheral neuropathy Respiratory, thoracic and mediastinal disorders Rare: interstitial lung disease (including interstitial pneumonitis), which may be fatal Gastrointestinal disorders Common: diarrhoea, nausea, vomiting, oral mucosal disorders (e.g., aphthous stomatitis, mouth ulceration), abdominal pain elevation of liver parameters (transaminases [especially ALT], less often gamma-GT, alkaline phosphatase, bilirubin) severe liver injury such as hepatic failure and acute hepatic necrosis that may be fatal Skin and subcutaneous tissue disorders Common: increased hair loss, eczema, rash (including maculopapular rash), pruritus, dry skin toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme cutaneous lupus erythematosus, pustular psoriasis or worsening psoriasis Musculoskeletal and connective tissue disorders Common: Renal and urinary disorders Not known: Reproductive system and breast disorders Not known: marginal (reversible) decreases in sperm concentration, total sperm count and rapid progressive motility General disorders and administration site conditions Common: anorexia, weight loss (usually insignificant), asthenia Overdose
Symptoms There have been reports of chronic overdose in patients taking Leflunomide medac at daily doses up to five times the recommended daily dose, and reports of acute overdose in adults and children. There were no adverse events reported in the majority of case reports of overdose. Adverse events consistent with the safety profile for leflunomide were: abdominal pain, nausea, diarrhoea, elevated liver enzymes, anaemia, leucopenia, pruritus and rash. Management In the event of an overdose or toxicity, colestyramine or charcoal is recommended to accelerate elimination. Colestyramine given orally at a dose of 8 g three times a day for 24 hours to three healthy volunteers decreased plasma levels of A771726 by approximately 40 % in 24 hours and by 49 % to
65 % in 48 hours.
Administration of activated charcoal (powder made into a suspension) orally or via nasogastric tube
(50 g every 6 hours for 24 hours) has been shown to reduce plasma concentrations of the active
metabolite A771726 by 37 % in 24 hours and by 48 % in 48 hours. These washout procedures may
be repeated if clinically necessary.
Studies with both hemodialysis and CAPD (chronic ambulatory peritoneal dialysis) indicate that
A771726, the primary metabolite of leflunomide, is not dialysable.
5.
PHARMACOLOGICAL PROPERTIES

5.1 Pharmacodynamic properties
Pharmacotherapeutic group: selective immunosuppressants, ATC code: L04AA13.
Human pharmacology
Leflunomide is a disease-modifying anti-rheumatic agent with antiproliferative properties.
Animal pharmacology
Leflunomide is effective in animal models of arthritis and of other autoimmune diseases and
transplantation, mainly if administered during the sensitisation phase. It has immunomodulating/
immunosuppressive characteristics, acts as an antiproliferative agent, and displays anti-inflammatory
properties. Leflunomide exhibits the best protective effects on animal models of autoimmune diseases
when administered in the early phase of the disease progression.
In vivo, it is rapidly and almost completely metabolised to A771726 which is active in vitro, and is
presumed to be responsible for the therapeutic effect.
Mechanism of action
A771726, the active metabolite of leflunomide, inhibits the human enzyme dihydroorotate
dehydrogenase (DHODH) and exhibits antiproliferative activity.
Clinical efficacy and safety
Rheumatoid arthritis
The efficacy of Leflunomide medac in the treatment of rheumatoid arthritis was demonstrated in 4
controlled trials (1 in phase II and 3 in phase III). The phase II trial, study YU203, randomised 402
subjects with active rheumatoid arthritis to placebo (n=102), leflunomide 5 mg (n=95), 10 mg (n=101)
or 25 mg/day (n=104). The treatment duration was 6 months.
All leflunomide patients in the phase III trials used an initial dose of 100 mg for 3 days.
Study MN301 randomised 358 subjects with active rheumatoid arthritis to leflunomide 20 mg/day
(n=133), sulphasalazine 2 g/day (n=133), or placebo (n=92). Treatment duration was 6 months.
Study MN303 was an optional 6-month blinded continuation of MN301 without the placebo arm,
resulting in a 12-month comparison of leflunomide and sulphasalazine.
Study MN302 randomised 999 subjects with active rheumatoid arthritis to leflunomide 20 mg/day
(n=501) or methotrexate at 7.5 mg/week increasing to 15 mg/week (n=498). Folate supplementation
was optional and only used in 10 % of patients. Treatment duration was 12-months.
Study US301 randomised 482 subjects with active rheumatoid arthritis to leflunomide 20 mg/day
(n=182), methotrexate 7.5 mg/week increasing to 15 mg/week (n=182), or placebo (n=118). All
patients received folate 1 mg bid. Treatment duration was 12 months.
Leflunomide at a daily dose of at least 10 mg (10 to 25 mg in study YU203, 20 mg in studies MN301
and US301) was statistically significantly superior to placebo in reducing the signs and symptoms of
rheumatoid arthritis in all 3 placebo-controlled trials. The ACR (American College of Rheumatology)
response rates in study YU203 were 27.7 % for placebo, 31.9 % for 5 mg, 50.5 % for 10 mg and
54.5 % for 25 mg/day. In the phase III trials, the ACR response rates for leflunomide 20 mg/day vs.
placebo were 54.6 % vs. 28.6 % (study MN301), and 49.4 % vs. 26.3 % (study US301). After 12
months with active treatment, the ACR response rates in leflunomide patients were 52.3 % (studies
MN301/303), 50.5 % (study MN302) and 49.4 % (study US301), compared to 53.8 % (studies
MN301/303) in sulphasalazine patients, 64.8 % (study MN302), and 43.9 % (study US301) in
methotrexate patients. In study MN302 leflunomide was significantly less effective than methotrexate.
However, in study US301 no significant differences were observed between leflunomide and
methotrexate in the primary efficacy parameters. No difference was observed between leflunomide
and sulphasalazine (study MN301). The leflunomide treatment effect was evident by 1 month,
stabilised by 3 to 6 months and continued throughout the course of treatment.
A randomised, double-blind, parallel-group non-inferiority study compared the relative efficacy of two
different daily maintenance doses of leflunomide, 10 mg and 20 mg. From the results it can be
concluded that efficacy results of the 20 mg maintenance dose were more favourable, on the other
hand, the safety results favoured the 10 mg daily maintenance dose.
Paediatric population
Leflunomide was studied in a single multicenter, randomized, double-blind, active-controlled trial in
94 patients (47 per arm) with polyarticular course juvenile rheumatoid arthritis. Patients were 3–17
years of age with active polyarticular course JRA regardless of onset type and naive to methotrexate or
leflunomide. In this trial, the loading dose and maintenance dose of leflunomide was based on three
weight categories: <20kg, 20-40 kg, and >40kg. After 16 weeks treatment, the difference in response
rates was statistically significant in favour of methotrexate for the JRA Definition of Improvement
(DOI) ≥30 % (p=0.02). In responders, this response was maintained during 48 weeks. (see section
4.2).
The pattern of adverse events of leflunomide and methotrexate seems to be similar, but the dose used
in lighter subjects resulted in a relatively low exposure (see section 5.2). These data do not allow an
effective and safe dose recommendation.
Postmarketing Studies

A randomised study assessed the clinical efficacy response rate in DMARD-naïve patients (n=121)
with early RA, who received either 20 mg or 100 mg of leflunomide with matching placebo in two
parallel groups during the initial three day double blind period. The initial period was followed by an
open label maintenance period of three months, during which both groups received leflunomide 20 mg
daily. The efficacy of leflunomide was confirmed in this study, but no incremental overall benefit was
observed in the studied population with the use of a loading dose regimen. The safety data obtained
from both treatment groups were consistent with the known safety profile of leflunomide, however,
the incidence of gastrointestinal adverse events and of elevated liver enzymes tended to be higher in
the patients receiving the loading dose of 100 mg leflunomide.
5.2
Pharmacokinetic properties
Leflunomide is rapidly converted to the active metabolite, A771726, by first-pass metabolism (ring opening) in gut wall and liver. In a study with radiolabelled 14C-leflunomide in three healthy volunteers, no unchanged leflunomide was detected in plasma, urine or faeces. In other studies, unchanged leflunomide levels in plasma have rarely been detected, however, at ng/ml plasma levels. The only plasma-radiolabelled metabolite detected was A771726. This metabolite is responsible for essentially all the in-vivo activity of Leflunomide medac. Absorption Excretion data from the 14C study indicated that at least about 82 to 95 % of the dose is absorbed. The time to peak plasma concentrations of A771726 is very variable; peak plasma levels can occur between 1 hour and 24 hours after single administration. Leflunomide can be administered with food, since the extent of absorption is comparable in the fed and fasting state. Due to the very long half-life of A771726 (approximately 2 weeks), a loading dose of 100 mg for 3 days was used in clinical studies to facilitate the rapid attainment of steady-state levels of A771726. Without a loading dose, it is estimated that attainment of steady-state plasma concentrations would require nearly two months of dosing. In multiple dose studies in patients with rheumatoid arthritis, the pharmacokinetic parameters of A771726 were linear over the dose range of 5 to 25 mg. In these studies, the clinical effect was closely related to the plasma concentration of A771726 and to the daily dose of leflunomide. At a dose level of 20 mg/day, average plasma concentration of A771726 at steady state is approximately 35 μg/ml. At steady state plasma levels accumulate about 33- to 35-fold compared with single dose. Distribution In human plasma, A771726 is extensively bound to protein (albumin). The unbound fraction of A771726 is about 0.62 %. Binding of A771726 is linear in the therapeutic concentration range. Binding of A771726 appeared slightly reduced and more variable in plasma from patients with rheumatoid arthritis or chronic renal insufficiency. The extensive protein binding of A771726 could lead to displacement of other highly-bound drugs. In vitro plasma protein binding interaction studies with warfarin at clinically relevant concentrations, however, showed no interaction. Similar studies showed that ibuprofen and diclofenac did not displace A771726, whereas the unbound fraction of A771726 is increased 2- to 3-fold in the presence of tolbutamide. A771726 displaced ibuprofen, diclofenac and tolbutamide but the unbound fraction of these drugs is only increased by 10 % to 50 %. There is no indication that these effects are of clinical relevance. Consistent with extensive protein binding A771726 has a low apparent volume of distribution (approximately 11 litres). There is no preferential uptake in erythrocytes. Biotransformation Leflunomide is metabolised to one primary (A771726) and many minor metabolites including TFMA (4-trifluoromethylaniline). The metabolic biotransformation of leflunomide to A771726 and subsequent metabolism of A771726 is not controlled by a single enzyme and has been shown to occur in microsomal and cytosolic cellular fractions. Interaction studies with cimetidine (non-specific cytochrome P450 inhibitor) and rifampicin (non-specific cytochrome P450 inducer), indicate that in vivo CYP enzymes are involved in the metabolism of leflunomide only to a small extent. Elimination Elimination of A771726 is slow and characterised by an apparent clearance of about 31 ml/hr. The elimination half-life in patients is approximately 2 weeks. After administration of a radiolabelled dose of leflunomide, radioactivity was equally excreted in faeces, probably by biliary elimination, and in urine. A771726 was still detectable in urine and faeces 36 days after a single administration. The principal urinary metabolites were glucuronide products derived from leflunomide (mainly in 0 to 24 hour samples) and an oxanilic acid derivative of A771726. The principal faecal component was A771726. It has been shown in man that administration of an oral suspension of activated powdered charcoal or
colestyramine leads to a rapid and significant increase in A771726 elimination rate and decline in
plasma concentrations (see section 4.9). This is thought to be achieved by a gastrointestinal dialysis
mechanism and/or by interrupting enterohepatic recycling.
Renal impairment
Leflunomide was administered as a single oral 100 mg dose to 3 haemodialysis patients and 3 patients
on continuous peritoneal dialysis (CAPD). The pharmacokinetics of A771726 in CAPD subjects
appeared to be similar to healthy volunteers. A more rapid elimination of A771726 was observed in
haemodialysis subjects which was not due to extraction of drug in the dialysate.
Hepatic impairment
No data are available regarding treatment of patients with hepatic impairment. The active metabolite
A771726 is extensively protein bound and cleared via hepatic metabolism and biliary secretion. These
processes may be affected by hepatic dysfunction.
Paediatric population
The pharmacokinetics of A771726 following oral administration of leflunomide have been
investigated in 73 paediatric patients with polyarticular course Juvenile Rheumatoid Arthritis (JRA)
who ranged in age from 3 to 17 years. The results of a population pharmacokinetic analysis of these
trials have demonstrated that paediatric patients with body weights ≤40 kg have a reduced systemic
exposure (measured by Css) of A771726 relative to adult rheumatoid arthritis patients (see section
4.2).
Elderly
Pharmacokinetic data in elderly (> 65 years) are limited but consistent with pharmacokinetics in
younger adults.
5.3
Preclinical safety data
Leflunomide, administered orally and intraperitoneally, has been studied in acute toxicity studies in mice and rats. Repeated oral administration of leflunomide to mice for up to 3 months, to rats and dogs for up to 6 months and to monkeys for up to 1 month's duration revealed that the major target organs for toxicity were bone marrow, blood, gastrointestinal tract, skin, spleen, thymus and lymph nodes. The main effects were anaemia, leucopenia, decreased platelet counts and panmyelopathy and reflect the basic mode of action of the compound (inhibition of DNA synthesis). In rats and dogs, Heinz bodies and/or Howell-Jolly bodies were found. Other effects found on heart, liver, cornea and respiratory tract could be explained as infections due to immunosuppression. Toxicity in animals was found at doses equivalent to human therapeutic doses. Leflunomide was not mutagenic. However, the minor metabolite TFMA (4-trifluoromethylaniline) caused clastogenicity and point mutations in vitro, whilst insufficient information was available on its potential to exert this effect in vivo. In a carcinogenicity study in rats, leflunomide did not show carcinogenic potential. In a carcinogenicity study in mice an increased incidence of malignant lymphoma occurred in males of the highest dose group, considered to be due to the immunosuppressive activity of leflunomide. In female mice an increased incidence, dose-dependent, of bronchiolo-alveolar adenomas and carcinomas of the lung was noted. The relevance of the findings in mice relative to the clinical use of leflunomide is uncertain. Leflunomide was not antigenic in animal models.
Leflunomide was embryotoxic and teratogenic in rats and rabbits at doses in the human therapeutic
range and exerted adverse effects on male reproductive organs in repeated dose toxicity studies.
Fertility was not reduced.
6.
PHARMACEUTICAL PARTICULARS
List of excipients

Tablet core:
lactose monohydrate
low-substituted hydroxypropyl cellulose
tartaric acid
sodium laurylsulfate
magnesium stearate
Film-coating:
lecithin (soybeans)
poly(vinyl alcohol)
talc
titanium dioxide (E171)
xanthan gum
Incompatibilities

Not applicable.
6.3
Shelf life

3 years.
6.4
Special precautions for storage

Keep the bottle tightly closed in order to protect from moisture.
6.5
Nature and contents of container

40 ml HDPE-wide-necked bottle, with screw cap with integrated desiccant container (white silica gel),
containing either 30, 60, 90 or 100 film-coated tablets.
Not all pack sizes may be marketed.
6.6
Special precautions for disposal

No special requirements for disposal.
7.
MARKETING AUTHORISATION HOLDER
medac Gesellschaft für klinische Spezialpräparate mbH Fehlandtstr. 3 20354 Hamburg Germany MARKETING AUTHORISATION NUMBER(S)

EU/1/10/637/001 (10 mg, 30 tablets)
EU/1/10/637/002 (10 mg, 60 tablets)
EU/1/10/637/003 (10 mg, 90 tablets)
EU/1/10/637/004 (10 mg, 100 tablets)

9.

DATE OF FIRST AUTHORISATION/RENEWAL OF THE AUTHORISATION

27.07.2010

10.

DATE OF REVISION OF THE TEXT
07/2013 Detailed information on this medicinal product is available on the website of the European Medicines Agency http://www.ema.europa.eu/.

Source: http://www.medac-uk.co.uk/assets/files/SPC%20Leflunomide%2010mg%2007_2013.pdf

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