Le tadalafil possède une affinité marquée pour la PDE5, mais épargne en grande partie les isoformes PDE1, PDE2 et PDE11, réduisant ainsi le risque d’effets extra-caverneux. L’action se traduit par une augmentation contrôlée de la circulation sanguine locale, indépendante des variations alimentaires. Sa pharmacocinétique repose sur une absorption digestive rapide, un métabolisme hépatique par CYP3A4 et une distribution tissulaire large. La biodisponibilité reste stable, et l’équilibre plasmatique est atteint en quelques jours lors d’administrations répétées. Les interactions cliniquement significatives surviennent avec les inhibiteurs puissants de CYP3A4 tels que le kétoconazole. Dans la littérature pharmacologique, acheter cialis 20 mg est souvent associé à des schémas d’utilisation basés sur la durée prolongée de son action.

Malaria

UNITED NATIONS OFFICE AT NAIROBI
JOINT MEDICAL SERVICE.

Malaria.
Malaria is a life-threatening disease caused by a
parasite and is transmitted via the bites of infected
mosquitoes (Plasmodium Anopheles mosquito ).

25th April every year- is a day of unified
commemoration of the global effort to provide
effective control of malaria around the world-world
malaria day.
Facts about Malaria
• Over 60%of the world’s population lives in • Malaria kills a child somewhere in the world • It infects 350-500 million people each year, killing 1 million, mostly children in Africa. • Ninety per cent of malaria deaths occur in • Over 30% of school absenteeism in Africa is attributed to malaria and other illnesses. • Malaria is both preventable and treatable. • Early diagnosis and treatment saves life.
Signs and Symptoms of malaria
These appear between 10 and 15 days after mosquito
bites but may occur even after 60 days, they include:
• Confusion,Hallucinations,Coma(unconsciousnes
Who is at increased risk for malaria?
• Travelers coming from areas with no malaria • Pregnant women and their unborn children. • Non immune persons while in malaria areas. • People with lowered immunity such as in HIV/Aids are usually worst hit by malaria. • Poverty, lack of knowledge, and little or no access to health care also contribute to malaria deaths worldwide Prevention of malaria
Use mosquito repellant nets-some chemicals such
as permethrin which is a chemical used as a
mosquito repellant sprayed on the clothes and
mosquito nets.
• Permethrin 0.5 to 1% is available in various chemists as over the counter medication which is effective for at least 2-6 weeks and may last for up to 1 year even through laundering if its concentration is higher such as in the already treated mosquito nets that last 1 to 4 years or in tablets used for treating mosquito nets. DEET (N, N-diethyl-m-tiluamide) is also approved
chemical for skin application on the exposed parts of
the body such as hands, legs as a mosquito repellant
which may last 4-6hours.Its available in 15-33% in
chemists and major hospital pharmacies and offers
97% protection.
• When combined DEET and Permethrin offers 99.9% protection against mosquitoes. Among locally available brands includes: Mijex gel/spray and Mosout spray. These chemicals are not harmful to the body as they are poorly absorbed, and are rapidly deactivated -their rare side effects include itching, redness and dizziness. They should not be applied to the eyes, mouth or broken skin. In addition:
• Wear clothing covering most body parts while in • Clear bushes, long grasses.
• Drain stagnant waters.
• Use of insecticides to kill mosquitoes. • All pregnant mothers should take appropriate malaria prophylaxis when going to malaria areas as directed by the Doctor. • Travelers should take prophylactic medication when going to malaria areas-per your Dr. • Seek medical advice for symptoms of malaria For more information contact-UNON JMS
at: clinical.staff@unon.org
Sources
www.malaria riskfactors:mayoclinic.com
www-malaria WHO
WWW-medicineNET.com
www.malaria signs,symptoms,prevention and
treatment
www.malaria lifecycle
www.Unicef health malaria
www.CDC –facts malaria
www.WHO 10 facts on malaria
www.navy medical Department Pocket Guide to Malaria
Prevention and Control
www.permethrin.wikipeda-the free encyclopedia
www.permethrin cream-topical side effects
www.repellents
www.permethrin 05905

Source: http://www.medical.unon.org/docs/malaria_info.pdf