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Questions about pesticides in foods

QUESTIONS ABOUT PESTICIDES ON FOODS
Robert J. Geller, M.D., F.A.A.P.
Associate Professor of Pediatrics
Emory University School of Medicine
AMERICAN COLLEGE OF MEDICAL TOXICOLOGY
www.acmt.net

Funded by the Agency for Toxic Substances and Disease Registry Cooperative
Agreement Number U61/ATU374416-01, Program Capacity to Conduct
Environmental Medicine and Health Education Activities
Produced in collaboration with the Association of Occupational and Environmental
Clinics and the Pediatric Environmental Health Specialty Unit Program
Monograph Editor:
Erica L. Liebelt M.D. FACMT
Associate Professor of Pediatrics and Emergency Medicine
University of Alabama at Birmingham School of Medicine
Director, Medical Toxicology Services at UAB Hospital and Children’s Hospital

Primary Peer Reviewers:

Larry K. Lowry Ph.D.
Co-Director, Southwest Center for Pediatric Environmental Health
The University of Texas Health Center at Tyler
Nathan M. Graber M.D.
Fellow in Pediatric Environmental Health
Mt. Sinai School of Medicine
• Pesticides and other agriculturally applied chemicals often are present in food. • These chemicals have been shown to also be present in people in small amounts. • There are many ways that children are exposed to these chemicals. One way is through the food they eat. They are also exposed by the household and garden use of pesticides, living on or near farms where the chemicals are used, and by chemicals carried home on the clothes and skin of parents who work with and around pesticides. • The levels of exposure from food are rarely high enough to cause symptoms but they can affect the developing child, especially if exposed while in the womb or in infancy or early childhood. • The risks from the pesticides in foods are small compared to the tremendous health benefits of eating fruits and vegetables. • Agricultural chemicals are also found in animal products such as meat and dairy. Most of those chemicals are stored in the fat of the animal, so reducing the amount of animal fat in the diet will reduce your exposure to toxic chemicals and also reduce the other risks associated with excessive cholesterol and fat intake.
Q. I’ve heard that foods are contaminated with pesticides. How does this happen?

A. Modern agricultural practices are designed to produce as much good-tasting,
appealing food as possible, and to minimize the amount of the crop that is spoiled by
insects or other pests. These practices often include the use of chemicals, including
pesticides used to protect food from pests, such as insects and rodents. Other chemicals
also are used in the process of growing food, such as fertilizers used to enhance plant
growth, herbicides to control weeds, fungicides to control mold and fungi, and
antimicrobials to control bacteria. Pesticides can also be present in the livestock and
fish’s food and water. Different chemicals are applied at different times during the
growing season, directed at the pests most likely to damage the crop at that time. The
prudent use of pesticides reduces insect or other pest damage to the crops while they are
growing. Proper agricultural practices can minimize the amount of pesticides present on
the foods at the time of harvest.
Some pesticides enter the system of the plant, while others remain on the surface of the
plant. Over a period of time, which varies from one crop to another, the systemic
pesticides leave the plant. If the crop is harvested too soon after application of a systemic
pesticide, a potentially dangerous amount of that pesticide may remain in the plant.
The best choice for a farmer regarding which pesticide to use at a certain time varies,
depending on the specific crop and the pests that need to be controlled at that point.
Pesticides can often be avoided altogether by appropriate growing conditions (such as
crop rotation practices) and use of less toxic alternatives. People growing fruits,
vegetables, and grains intended for consumption should use pesticides only when needed,
and only in the amount and timing recommended on the product label or by an
Agricultural Extension Agent.
• In summary, foods often contain some chemicals used in the growing process at the
time they are sold for human consumption. The foods should contain as little of these
added chemicals as possible and certainly less than the amount that causes effects on
people.

Q. I’ve heard that some pesticides found in foods are safer than others. Is this true?

A. Yes, it is true. The toxicity of pesticides depends on several factors, including, the
amount of time required for the chemical to break down to non-toxic materials (often
measured in “half-lifes”, the time required for half of the chemical to be broken down),
how quickly it is eliminated from the body, whether or not it is metabolized (broken
down) in the body, whether the products of metabolism are also toxic and whether or not
it is used in combination with other pesticides that can have an additive effect. In general,
the mechanism for toxicity is similar in both humans and insects, but much more
pesticide is required to harm a person than an insect.
Several different types of insecticides and other pesticides are widely used in the United
States. Outside the United States, other chemicals may be used in addition to those used
in the U.S. All pesticides currently in use within the United States must be approved by
the United States Environmental Protection Agency (called “registration”) and then also
by the Department of Agriculture in the state in which they are to be used. This
registration process reviews the safety and effectiveness of the chemical, but each
nonetheless poses risks if used inappropriately. The Food Quality Protection Act of
1996 requires that the EPA carefully evaluate children's exposure to pesticide residues in
and on foods they most commonly eat, i.e., apples and apple juice, orange juice, potatoes,
tomatoes, soybean oil, sugar, eggs, pork, chicken and beef. The EPA is also evaluating
new and existing pesticides to ensure that they can be used with a reasonable certainty of
no harm to adults as well as infants and children. This review also establishes the amount
of each chemical that is allowed to be present in the food at the time it is sold in the U.S.,
considering the potential for some individuals to be vulnerable than others and trying to
keep them safe as well.
The following pesticides are listed in order of relative frequency of use, not degree of
toxicity.
* Organophosphate pesticides account for about one half of the insecticides used in the
U.S. Organophosphate and carbamate insecticides (such as malathion, diazinon, guthion,
azinphos, and chlorpyrifos) have been used extensively for more than 50 years. Excessive
human exposure to these agents may result in clinically evident toxic effects. In addition,
clinical effects may be difficult to separate distinguish from other illnesses.
Carbamates and organophosphates are cholinesterase inhibitors that kill insects by
interfering with the proper functioning of their central nervous system. Cholinesterases
are enzymes that are required to “turn off” signals once they are transmitted from one
neuron to another within the nervous system. Preventing these enzymes from acting
leaves the neuron that is receiving the message locked in the “on” position. Most animals
have a reserve amount of cholinesterase activity, more than is needed to maintain normal
function. Symptoms occur only when the amount of cholinesterase inhibition
substantially exceeds the amount needed to maintain function. Insects are more sensitive
to these agents than most people, which explains why insects can be killed while the people nearby are not adversely affected. Cholinesterase inhibition can also occur in humans. The effects commonly noted after poisoning by these agents include a combination of nausea, vomiting, stomach cramps, diarrhea, excessive drooling and tearing, muscular weakness, and muscle tremors. Young children, however, may display sedation and other behavioral effects instead of these typical cholinesterase symptoms. Lingering effects have also been described, particularly after intense exposures. * Carbamate compounds act similarly to organophosphates but the binding to acetylcholinesterase is reversible. Therefore, they have a shorter period of effect. Examples of carbamates include carbaryl, aldicarb, and propoxur. They are often less toxic to people than organophosphates, at similar doses. * Pyrethroid compounds are less toxic to people than organophosphates and carbamates. They are derived from chrysanthemums and are preferred for their rapid breakdown in the environment and low toxicity in humans. They occasionally produce allergic-like reactions in people and can exacerbate asthma. Examples of pyrethroids include pyrethroid, pyrethrin, resmethrin, and cypermethrin. These compounds affect the enzymes regulating insect wing motion, enzymes not found in humans. *Soap-based insecticides are used as an alternative to organophosphates, carbamates, and pyrethroids. These products are often obtained from natural sources. These compounds have very low toxic potential to humans. * Long-acting anticoagulant rodenticides are used to kill rats, mice, and related pests. They act by preventing the blood of the animal from clotting after even minor injury, resulting in the pest bleeding to death. Because of the manner in which they are used in pest control, it is unlikely that they would get onto foods in sufficient quantity to pose a problem to humans or pets. * Arsenic based pesticides have been used to control insects and rodents in the past. They are highly toxic to both animals and people, and are restricted to licensed pest control applicators in most U.S. jurisdictions. This class of compounds generally should not be used on products intended to be eaten. * Zinc phosphide based pesticides have been used as fumigants to control insects and rodents in the past. They are highly toxic to both animals and people. Their chief advantage is their short life-span in the environment before decomposing. They are generally restricted to licensed pest control applicators. They leave little if any residue on the surface of foods treated with this agent. • In summary, the safest pesticides will have little effect on the person, do its intended job quickly and effectively, and then break down quickly in the environment. At the same time, this ideal amount that is absorbed into the human body would be broken down
swiftly and efficiently into non-toxic compounds.
Q. I’ve heard that some people are at higher risk from pesticides than others. Why?

A. Variations in the ability of people to break down chemicals in their bodies occur
because of genetic differences between individuals and changes that occur as people
grow from infancy to adulthood. Individuals with low normal values before any exposure
who are very young, or who take medications that alter cholinesterase activity, may be at
higher risk from organophosphate or carbamate insecticides. For instance, among healthy
people, the normal amount of cholinesterase enzyme activity varies greatly between
individuals. If the average normal cholinesterase activity is defined as 100%, then the
normal range of activity is as large as 50% to 150% of the average value. The
implication of this fact for people exposed to organophosphates or carbamates is that,
where two people are exposed to the same amount of these pesticides, one can be
extremely symptomatic and the other person can have no symptoms at all. Young infants
may not yet have the enzymes to breakdown these compounds or may do so more slowly
than adults. At the same time, children and infants may be exposed to much more
pesticides per pound of body weight than adults in the same environment eating the same
foods(see “I’ve heard that infants are at higher risk…” below for more details).
Some medications can slow down the metabolism of specific pesticides (particularly
organophosphate insecticides). Medications that alter cholinesterase activity include, for
example, some used to treat Alzheimer’s Disease and related conditions (e.g., donepezil
[Aricept®], galantamine [Reminyl®], rivastigmine [Exelon®], tacrine [Cognex®]), and
some used to treat conditions such as myasthenia gravis (e.g., pyridostigmine
[Mestinon®]). Also, individuals who have been exposed to these cholinesterase
inhibitors, occupationally or from leisure activities (e.g., gardening) may be more
susceptible upon further exposure.
• In summary, some people are at increased risk of effects from pesticides. This may
occur because of their genetic makeup, age, other exposures, illnesses, or other
medications they use.


Q. I’ve heard that infants are at higher risk than adults. Why?

A. Infants and children are at a higher risk for exposure to pesticides and may be more
susceptible to the toxic effects of these chemicals than adults.
Infants and children may be especially sensitive to health risks posed by pesticides for
several reasons:
• Their internal organs are still developing and maturing. • In relation to their body weight, infants and children eat and drink more than adults, possibly increasing their exposure to pesticides in food and water. • Certain behaviors--such as playing on floors or lawns or putting objects in their mouths--increase a child's exposure to pesticides used in homes and yards. Pesticides may harm a developing child by blocking the absorption of important food nutrients necessary for normal healthy growth. Infants have immature metabolic systems at birth, which gradually mature within the first few years of life. Both the infant’s ability to metabolize (break down) various chemical compounds, and the infant’s ability to eliminate them from their body through the urine, stool, or breathing may be reduced from that of an adult. This is because most of the enzymatic systems’ maturation occurs within the first few months of life. Infants also have a different exposure pattern to environmental chemicals than adults, for multiple reasons: • The diets of infants and children are different than adults diets. The child diet often is less varied. For example, toddlers eat disproportionately more apples, applesauce and apple juice and disproportionately more potato (much of it as “French Fries”) than adults. This difference in diet results in chemical residues in apples and potatoes being eaten by children in relatively larger amounts; it is estimated to be as much as 16 times more potatoes and 4 times more apples than typical adults, based on the person’s body weight. Children also drink more water than adults, as a component of infant formula and juice. For this reason, chemicals on or in water, apples, and potatoes may have a larger effect on infants and young children. Breast milk is a substantial water source for breast-fed infants, but the water is filtered by the mother’s body which may or may not remove a specific chemical from the breast milk. • Infants spend more of their time close to the ground, crawling or lying on the floor. This is where compounds that are heavier than air concentrate and the child breathes them in. They also get exposed to dust (which may contain pesticide residues) settled on the floor, which children can place in their mouths through normal hand to mouth behaviors. • Infants breathe faster than adults. Normal infant respiratory rates are 20 - 40 breaths per minute, while adults typically breathe 8 – 12 times each minute. Infants are exposed to more air per minute per kilogram of body weight than adults, leading to the possibility of higher absorption of chemicals that they inhale. • Infants have a larger surface area of skin compared to their weight, leading to possibly greater intake of chemicals absorbed through the skin.
Also, for some chemicals, there are "critical periods" in fetal and infant human
development when exposure to the chemicals can permanently alter the way an
individual's biological system operates. The window of time during which this occurs
varies, depending on the specific compound.
• In summary, young infants are at potentially increased risk from pesticides and other
agricultural chemicals because of their dietary habits (which may lead to relatively
increased intake compared to adults), their metabolic immaturity, and their ongoing
growth.
Q. I’ve encountered conflicting opinions about the safety of certain chemicals from
different experts. Why is there such disagreement?

A. The data that is available to judge safety is limited. Much of it comes from animal
studies, and it is difficult to determine exactly how to apply this information to people.
Humans may be more or less sensitive than the species in which the tests were carried
out, and certain effects occur only in specific species or only at certain stages of
development in the womb. For example, thalidomide is a drug that causes incomplete
development of arms when the human fetus is exposed at a specific stage of
development, but this effect occurs in only a few species and was not observed in animal
studies conducted before human use. Some fungicides, such as Captan®, in current use
are chemically related to thalidomide, but the significance of this relationship is unclear.
Some organophosphates have chemical structures that mimic male or female sex
hormones, raising the concern that they may impact the fetus and the young infant during
their early development. This has been clearly demonstrated to occur in relatively
uncomplicated organisms, but the same effect has not been shown in large animals or
people. The relevance of this finding to health effects in humans is not yet clear.
Most regulatory agencies use the best data available, and then apply “safety factors”
intended to compensate for these uncertainties. For example, the United States
Environmental Protection Agency applies a 10-fold safety factor to compensate for
differences between individuals, then another 10-fold safety factor to compensate for
differences between species. Since late 2001, the U.S. EPA has been applying yet another
10-fold safety factor to compensate for differences between human infants and human
adults. Despite these safety factors, good scientific data does not exist at this time to
determine if the regulatory limits resulting from application of these safety factors
provide too much or too little protection.
• In summary, the safety data that is available is limited, with much of it coming from
animal data. It is hard to tell exactly how this applies to people. Various experts have
arrived at differing conclusions based on the same data.

Q. Can I wash pesticides off of my foods before eating?

A. Systemic pesticides are incorporated within the plant, and cannot be washed off. Non-
systemic pesticides are on the surface of the plant. The amount of non-systemic pesticides
on the surface of the fruit or vegetable can be reduced by washing the food with soap and
water. As pediatricians, we don’t recommend peeling when it is no longer a choking
hazard since the peel contains dietary fiber and nutrients that are not necessarily found in
the “meat” of the plant.
• In summary, the extent to which pesticides can be washed off of foods varies depending
on the chemical and the time lapse between the chemical application and the time of
eating.
Q. What about meats and poultry? Should I worry about them?

A. Most commercially grown meat and poultry have been exposed to various chemicals
during the raising period. It is difficult for the consumer to determine which chemicals
have been used and also difficult to determine how much remain. The U.S. Food and
Drug Administration has imposed standards to govern against the use of chemicals which
pose the most risk in implementing the Food Quality Protection Act of 1996. Consumers
who remain concerned may consider purchasing “Certified Organic” produce, poultry,
and beef. However, it is unclear whether the additional cost of “Certified Organic” food
reduces overall risk of harm from food.
When purchasing “organic” food, be aware that these foods may not be nutritionally
fortified with recommended vitamins and minerals. Such vitamins and minerals include
the addition of small amounts of iron to infant formula, folate to bread, iodine to salt,
vitamin D to milk. This practice has been shown to reduce the frequency and severity of
conditions such as iron deficiency causing anemia, folate causing congenital defects in
newborn infants, iodine deficiency causing thyroid disease, and vitamin D reducing bone
problems such as rickets.

SUMMARY RECOMMENDATIONS:

• Pesticides and other agriculturally applied chemicals often are present in food and • Children are exposed to pesticides by varied routes, including through the food they eat, but the amount of exposure is rarely high enough to cause symptoms. However, some children, particularly the fetus and young infant, are at an increased risk from these chemicals. • The risks from the pesticides in foods are small compared to the tremendous health benefits of eating fruits and vegetables. • Agricultural chemicals are also found in animal products such as meat and dairy. Most of those chemicals are stored in the fat of the animal, so reducing the amount of animal fat in the diet will reduce your exposure to these chemicals as well as reduce other health risks associated with diets high in animal fat.
Sources for Additional Reading
Note: each of these publications has extensive references to buttress their points, and
may be worth exploring for this reason if none other.

American Academy of Pediatrics Committee on Environmental Health. Etzel RA, Balk
SJ, editors. Pediatric Environmental Health, 2nd Edition. Elk Grove Village, IL: American
Academy of Pediatrics; 2003.
Brent RL, Tanski S, Weitzman M. A Pediatric Perspective on the Unique Vulnerability
and Resilience of the Embryo and the Child to Environmental Toxicants: The Importance
of Rigorous Research Concerning Age and Agent. Pediatrics 2004; 113 (4 Supplement):
935-944.
Garry VF. Pesticides and Children. Toxicol Appl Pharmacol 2004; 198: 152-163.
Kamel F, Hoppin JA. Association of Pesticide Exposure with Neurologic Dysfunction
and Disease. Environ Health Perspect 2004; 112 (9): 950-958.
Reigart JR, Roberts JR. Pesticides in Children. Ped Clin N Am 2001; 48 (5): 1185-98.
Weiss B, Amler S, Amler RW. Pesticides. Pediatrics 2004; 113 (4 Supplement): 1030-
1036.

Source: http://video.acmt.net/_Library/docs/Pesticides_Final_106.pdf

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